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- NCIT_C2472 IAO_0000115 "A recombinant disulfide stabilized anti-Lewis Y IgG immunotoxin containing a 38 KD toxic element derived from the Pseudomonas aeruginosa exotoxin A and a monoclonal antibody fragment, designed to target adenocarcinomas expressing Lewis Y. LMB-9 immunotoxin attaches to tumor cells, facilitating he entry of the exotoxin. The exotoxin moiety induces caspase-mediated apoptosis of tumor cells via a mechanism involving mitochondrial damage; it also catalyzes the transfer of ADP ribose from nicotinamide adenine dinucleotide (NAD) to elongation factor-2 in eukaryotic cells, thereby inactivating elongation factor 2 and inhibiting protein synthesis." @default.
- NCIT_C2472 NCIT_A32 NCIT_C1909 @default.
- NCIT_C2472 NCIT_NHC0 "C2472" @default.
- NCIT_C2472 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C2472 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C2472 NCIT_P108 "LMB-9 Immunotoxin" @default.
- NCIT_C2472 NCIT_P175 "691236" @default.
- NCIT_C2472 NCIT_P207 "C0678023" @default.
- NCIT_C2472 NCIT_P322 "GDC" @default.
- NCIT_C2472 NCIT_P325 "A toxic substance linked to an antibody that attaches to tumor cells and kills them." @default.
- NCIT_C2472 NCIT_P329 "43018" @default.
- NCIT_C2472 NCIT_P330 "43018" @default.
- NCIT_C2472 NCIT_P366 "LMB-9_Immunotoxin" @default.
- NCIT_C2472 NCIT_P375 "LMB-9 Immunotoxin" @default.
- NCIT_C2472 NCIT_P399 "43018" @default.
- NCIT_C2472 NCIT_R124 NCIT_C16956 @default.
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- NCIT_C2472 NCIT_R125 NCIT_C17557 @default.
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- NCIT_C2472 NCIT_R125 NCIT_C41515 @default.
- NCIT_C2472 NCIT_R146 NCIT_C17021 @default.
- NCIT_C2472 NCIT_R146 NCIT_C20027 @default.
- NCIT_C2472 NCIT_R146 NCIT_C26548 @default.
- NCIT_C2472 NCIT_R146 NCIT_C38576 @default.
- NCIT_C2472 NCIT_R146 NCIT_C38586 @default.
- NCIT_C2472 normalizedInformationContent "100" @default.
- NCIT_C2472 referenceCount "1" @default.
- NCIT_C2472 hasExactSynonym "B3 (dsFv)-PE38" @default.
- NCIT_C2472 hasExactSynonym "Immunotoxin LMB-9" @default.
- NCIT_C2472 hasExactSynonym "LMB-9 Immunotoxin" @default.
- NCIT_C2472 hasExactSynonym "LMB-9 immunotoxin" @default.
- NCIT_C2472 hasExactSynonym "LMB-9" @default.
- NCIT_C2472 inSubset NCIT_C128784 @default.
- NCIT_C2472 inSubset NCIT_C157711 @default.
- NCIT_C2472 inSubset NCIT_C157712 @default.
- NCIT_C2472 inSubset NCIT_C176424 @default.
- NCIT_C2472 inSubset NCIT_C177537 @default.
- NCIT_C2472 type Class @default.
- NCIT_C2472 isDefinedBy ncit.owl @default.
- NCIT_C2472 label "LMB-9 Immunotoxin" @default.
- NCIT_C2472 subClassOf B1610bef0ee673439452308ebc3038a97 @default.
- NCIT_C2472 subClassOf B4cba87e82fcd4f1b9701d4a98fef785d @default.
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- NCIT_C2472 subClassOf NCIT_C1512 @default.
- NCIT_C2472 subClassOf NCIT_C1908 @default.
- NCIT_C2472 subClassOf NCIT_C1909 @default.
- NCIT_C2472 subClassOf NCIT_C2472 @default.
- NCIT_C2472 subClassOf NCIT_C307 @default.
- NCIT_C2472 subClassOf NCIT_C308 @default.
- NCIT_C2472 subClassOf NCIT_C575 @default.
- NCIT_C2472 subClassOf NCIT_C78532 @default.