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- NCIT_C2487 IAO_0000115 "A synthetic, biodegradable wafer containing the agent carmustine with antineoplastic activity. Used to deliver drug directly into a brain tumor site and typically implanted post-surgically, the wafer is made of a biodegradable poly-anhydride copolymer and contains the nitrosourea carmustine. As an antineoplastic nitrosourea, carmustine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. Carmustine also carbamoylates proteins, including DNA repair enzymes, resulting in an enhanced cytotoxic effect. Carmustine is highly lipophilic and crosses the blood-brain barrier readily. (NCI04)" @default.
- NCIT_C2487 NCIT_A32 NCIT_C1909 @default.
- NCIT_C2487 NCIT_NHC0 "C2487" @default.
- NCIT_C2487 NCIT_P106 "Organic Chemical" @default.
- NCIT_C2487 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C2487 NCIT_P107 "Carmustine Implant" @default.
- NCIT_C2487 NCIT_P108 "Carmustine Implant" @default.
- NCIT_C2487 NCIT_P175 "714372" @default.
- NCIT_C2487 NCIT_P208 "CL381677" @default.
- NCIT_C2487 NCIT_P302 "Malignant glioma, adjuvant to surgery and radiation; Recurrent glioblastoma multiforme, adjuvant to surgery" @default.
- NCIT_C2487 NCIT_P322 "CTRP" @default.
- NCIT_C2487 NCIT_P322 "GDC" @default.
- NCIT_C2487 NCIT_P325 "A biodegradable wafer that is used to deliver the anticancer drug carmustine directly into a brain tumor site after the tumor has been removed by surgery." @default.
- NCIT_C2487 NCIT_P329 "43142" @default.
- NCIT_C2487 NCIT_P330 "43142" @default.
- NCIT_C2487 NCIT_P366 "Polifeprosan_20_with_Carmustine_Implant" @default.
- NCIT_C2487 NCIT_P375 "Carmustine Implant" @default.
- NCIT_C2487 NCIT_P399 "43142" @default.
- NCIT_C2487 normalizedInformationContent "92.730304365937428" @default.
- NCIT_C2487 referenceCount "3" @default.
- NCIT_C2487 hasExactSynonym "BCNU Wafer" @default.
- NCIT_C2487 hasExactSynonym "Carmustine Copolymer" @default.
- NCIT_C2487 hasExactSynonym "Carmustine Implant" @default.
- NCIT_C2487 hasExactSynonym "Carmustine Wafer" @default.
- NCIT_C2487 hasExactSynonym "Carmustine Wafers" @default.
- NCIT_C2487 hasExactSynonym "Gliadel Wafer" @default.
- NCIT_C2487 hasExactSynonym "Gliadel Wafers" @default.
- NCIT_C2487 hasExactSynonym "Gliadel" @default.
- NCIT_C2487 hasExactSynonym "Polifeprosan 20 with Carmustine Implant" @default.
- NCIT_C2487 hasExactSynonym "polifeprosan 20 carmustine implant" @default.
- NCIT_C2487 inSubset NCIT_C116977 @default.
- NCIT_C2487 inSubset NCIT_C116978 @default.
- NCIT_C2487 inSubset NCIT_C128784 @default.
- NCIT_C2487 inSubset NCIT_C157711 @default.
- NCIT_C2487 inSubset NCIT_C157712 @default.
- NCIT_C2487 inSubset NCIT_C176424 @default.
- NCIT_C2487 inSubset NCIT_C177537 @default.
- NCIT_C2487 type Class @default.
- NCIT_C2487 isDefinedBy ncit.owl @default.
- NCIT_C2487 label "Carmustine Implant" @default.
- NCIT_C2487 subClassOf NCIT_C1590 @default.
- NCIT_C2487 subClassOf NCIT_C186664 @default.
- NCIT_C2487 subClassOf NCIT_C1908 @default.
- NCIT_C2487 subClassOf NCIT_C1909 @default.
- NCIT_C2487 subClassOf NCIT_C2487 @default.
- NCIT_C2487 subClassOf NCIT_C274 @default.
- NCIT_C2487 subClassOf NCIT_C2842 @default.
- NCIT_C2487 subClassOf NCIT_C699 @default.