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- NCIT_C2502 IAO_0000115 "A synthetic formulation in which the antineoplastic agent cisplatin is encapsulated in lipids. Cisplatin liposomal consists of small aggregates of cisplatin covered by a single lipid bilayer. Encasement in liposomes improves cisplatin's tumor bioavailability and toxicity profile. Liposomal encapsulation does not affect the pharmacological properties of cisplatin directly. Cisplatin forms highly reactive, charged, platinum complexes which bind to nucleophilic groups such as GC-rich sites in DNA, inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These cross-links result in apoptosis and cell growth inhibition. (NCI04)" @default.
- NCIT_C2502 NCIT_A32 NCIT_C1909 @default.
- NCIT_C2502 NCIT_NHC0 "C2502" @default.
- NCIT_C2502 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C2502 NCIT_P108 "Cisplatin Liposomal" @default.
- NCIT_C2502 NCIT_P175 "719334" @default.
- NCIT_C2502 NCIT_P207 "C0964924" @default.
- NCIT_C2502 NCIT_P322 "GDC" @default.
- NCIT_C2502 NCIT_P329 "43292" @default.
- NCIT_C2502 NCIT_P330 "43292" @default.
- NCIT_C2502 NCIT_P366 "Cisplatin_Liposomal" @default.
- NCIT_C2502 NCIT_P375 "Cisplatin Liposomal" @default.
- NCIT_C2502 NCIT_P399 "43292" @default.
- NCIT_C2502 normalizedInformationContent "100" @default.
- NCIT_C2502 referenceCount "1" @default.
- NCIT_C2502 hasExactSynonym "Cisplatin Liposomal" @default.
- NCIT_C2502 hasExactSynonym "Cisplatin, Liposomal" @default.
- NCIT_C2502 hasExactSynonym "Liposomal Cisplatin" @default.
- NCIT_C2502 hasExactSynonym "SPI-077" @default.
- NCIT_C2502 hasExactSynonym "SPI-77" @default.
- NCIT_C2502 hasExactSynonym "STEALTH Cisplatin" @default.
- NCIT_C2502 hasExactSynonym "STEALTH Liposomal Cisplatin" @default.
- NCIT_C2502 hasExactSynonym "STEALTH Liposomal Encapsulated Cisplatin" @default.
- NCIT_C2502 hasExactSynonym "STEALTH Liposome Cisplatin" @default.
- NCIT_C2502 inSubset NCIT_C128784 @default.
- NCIT_C2502 inSubset NCIT_C157711 @default.
- NCIT_C2502 inSubset NCIT_C157712 @default.
- NCIT_C2502 inSubset NCIT_C176424 @default.
- NCIT_C2502 inSubset NCIT_C177537 @default.
- NCIT_C2502 type Class @default.
- NCIT_C2502 isDefinedBy ncit.owl @default.
- NCIT_C2502 label "Cisplatin Liposomal" @default.
- NCIT_C2502 subClassOf NCIT_C1450 @default.
- NCIT_C2502 subClassOf NCIT_C1590 @default.
- NCIT_C2502 subClassOf NCIT_C186664 @default.
- NCIT_C2502 subClassOf NCIT_C1908 @default.
- NCIT_C2502 subClassOf NCIT_C1909 @default.
- NCIT_C2502 subClassOf NCIT_C2163 @default.
- NCIT_C2502 subClassOf NCIT_C2502 @default.
- NCIT_C2502 subClassOf NCIT_C274 @default.
- NCIT_C2502 subClassOf NCIT_C2842 @default.
- NCIT_C2502 subClassOf NCIT_C798 @default.