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- NCIT_C2503 IAO_0000115 "The disodium salt of a water-soluble phosphate derivative of a natural stilbenoid phenol derived from the African bush willow (Combretum caffrum) with potential vascular disrupting and antineoplastic activities. Upon administration, the prodrug fosbretabulin is dephosphorylated to its active metabolite, the microtubule-depolymerizing agent combretastatin A4, which binds to tubulin dimers and prevents microtubule polymerization, resulting in mitotic arrest and apoptosis in endothelial cells. In addition, this agent disrupts the engagement of the endothelial cell-specific junctional molecule vascular endothelial-cadherin (VE-cadherin) and so the activity of the VE-cadherin/beta-catenin/Akt signaling pathway, which may result in the inhibition of endothelial cell migration and capillary tube formation. As a result of fosbretabulin's dual mechanism of action, the tumor vasculature collapses, resulting in reduced tumor blood flow and ischemic necrosis of tumor tissue." @default.
- NCIT_C2503 NCIT_A32 NCIT_C1909 @default.
- NCIT_C2503 NCIT_A6 NCIT_C82378 @default.
- NCIT_C2503 NCIT_A7 NCIT_C17219 @default.
- NCIT_C2503 NCIT_NHC0 "C2503" @default.
- NCIT_C2503 NCIT_P106 "Organic Chemical" @default.
- NCIT_C2503 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C2503 NCIT_P107 "Fosbretabulin Disodium" @default.
- NCIT_C2503 NCIT_P108 "Fosbretabulin Disodium" @default.
- NCIT_C2503 NCIT_P207 "C0962508" @default.
- NCIT_C2503 NCIT_P210 "222030-63-9" @default.
- NCIT_C2503 NCIT_P319 "702RHR475O" @default.
- NCIT_C2503 NCIT_P322 "CTRP" @default.
- NCIT_C2503 NCIT_P322 "FDA" @default.
- NCIT_C2503 NCIT_P322 "GDC" @default.
- NCIT_C2503 NCIT_P329 "43316" @default.
- NCIT_C2503 NCIT_P330 "43316" @default.
- NCIT_C2503 NCIT_P350 "C18H19O8P.2Na" @default.
- NCIT_C2503 NCIT_P366 "Combretastatin_A4_Phosphate" @default.
- NCIT_C2503 NCIT_P375 "Fosbretabulin Disodium" @default.
- NCIT_C2503 NCIT_P399 "43316" @default.
- NCIT_C2503 NCIT_R124 NCIT_C17828 @default.
- NCIT_C2503 NCIT_R124 NCIT_C20480 @default.
- NCIT_C2503 NCIT_R124 NCIT_C40795 @default.
- NCIT_C2503 NCIT_R124 NCIT_C40798 @default.
- NCIT_C2503 normalizedInformationContent "100" @default.
- NCIT_C2503 referenceCount "1" @default.
- NCIT_C2503 hasExactSynonym "2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl Disodium Phosphate" @default.
- NCIT_C2503 hasExactSynonym "CA4DP" @default.
- NCIT_C2503 hasExactSynonym "Combretastatin A4 Disodium Phosphate" @default.
- NCIT_C2503 hasExactSynonym "FOSBRETABULIN DISODIUM" @default.
- NCIT_C2503 hasExactSynonym "Fosbretabulin Disodium" @default.
- NCIT_C2503 hasExactSynonym "Phenol, 2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]-, Dihydrogen Phosphate, Disodium Salt" @default.
- NCIT_C2503 inSubset NCIT_C116977 @default.
- NCIT_C2503 inSubset NCIT_C116978 @default.
- NCIT_C2503 inSubset NCIT_C128784 @default.
- NCIT_C2503 inSubset NCIT_C157711 @default.
- NCIT_C2503 inSubset NCIT_C157712 @default.
- NCIT_C2503 inSubset NCIT_C176424 @default.
- NCIT_C2503 inSubset NCIT_C177537 @default.
- NCIT_C2503 inSubset NCIT_C63923 @default.
- NCIT_C2503 type Class @default.
- NCIT_C2503 isDefinedBy ncit.owl @default.
- NCIT_C2503 label "Fosbretabulin Disodium" @default.
- NCIT_C2503 subClassOf NCIT_C186664 @default.
- NCIT_C2503 subClassOf NCIT_C1908 @default.
- NCIT_C2503 subClassOf NCIT_C1909 @default.
- NCIT_C2503 subClassOf NCIT_C2503 @default.
- NCIT_C2503 subClassOf NCIT_C25974 @default.
- NCIT_C2503 subClassOf NCIT_C273 @default.
- NCIT_C2503 subClassOf NCIT_C274 @default.
- NCIT_C2503 subClassOf NCIT_C67421 @default.