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- NCIT_C2507 IAO_0000115 "An orally bioavailable, small-molecule, bisindolylmaleimide cell cycle inhibitor with potential antineoplastic activity. MKC-1 and its metabolites inhibit tubulin polymerization, blocking the formation of the mitotic spindle, which may result in cell cycle arrest at the G2/M phase and apoptosis. In addition, this agent has been shown to inhibit the activities of the oncogenic kinase Akt, the mTOR pathway, and importin-beta, a protein essential to the transport of other proteins from the cytosol into the nucleus." @default.
- NCIT_C2507 NCIT_A32 NCIT_C1909 @default.
- NCIT_C2507 NCIT_A7 NCIT_C17219 @default.
- NCIT_C2507 NCIT_NHC0 "C2507" @default.
- NCIT_C2507 NCIT_P106 "Organic Chemical" @default.
- NCIT_C2507 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C2507 NCIT_P107 "MKC-1" @default.
- NCIT_C2507 NCIT_P108 "MKC-1" @default.
- NCIT_C2507 NCIT_P207 "C0796487" @default.
- NCIT_C2507 NCIT_P210 "125313-92-0" @default.
- NCIT_C2507 NCIT_P319 "DNZ11VPY7Q" @default.
- NCIT_C2507 NCIT_P322 "CTRP" @default.
- NCIT_C2507 NCIT_P322 "FDA" @default.
- NCIT_C2507 NCIT_P322 "GDC" @default.
- NCIT_C2507 NCIT_P325 "A substance that is being studied in the treatment of cancer. It may prevent cancer cells from dividing. It belongs to the family of drugs called cell cycle inhibitors." @default.
- NCIT_C2507 NCIT_P329 "486351" @default.
- NCIT_C2507 NCIT_P330 "486351" @default.
- NCIT_C2507 NCIT_P350 "C22H16N4O4" @default.
- NCIT_C2507 NCIT_P366 "Ro_31-7453" @default.
- NCIT_C2507 NCIT_P375 "MKC-1" @default.
- NCIT_C2507 NCIT_P399 "486351" @default.
- NCIT_C2507 NCIT_R124 NCIT_C17828 @default.
- NCIT_C2507 NCIT_R124 NCIT_C20480 @default.
- NCIT_C2507 NCIT_R124 NCIT_C40795 @default.
- NCIT_C2507 NCIT_R124 NCIT_C40798 @default.
- NCIT_C2507 normalizedInformationContent "100" @default.
- NCIT_C2507 referenceCount "1" @default.
- NCIT_C2507 hasExactSynonym "MKC-1" @default.
- NCIT_C2507 hasExactSynonym "R440" @default.
- NCIT_C2507 hasExactSynonym "Ro 31-7453" @default.
- NCIT_C2507 inSubset NCIT_C116977 @default.
- NCIT_C2507 inSubset NCIT_C116978 @default.
- NCIT_C2507 inSubset NCIT_C128784 @default.
- NCIT_C2507 inSubset NCIT_C157711 @default.
- NCIT_C2507 inSubset NCIT_C157712 @default.
- NCIT_C2507 inSubset NCIT_C176424 @default.
- NCIT_C2507 inSubset NCIT_C177537 @default.
- NCIT_C2507 inSubset NCIT_C63923 @default.
- NCIT_C2507 type Class @default.
- NCIT_C2507 isDefinedBy ncit.owl @default.
- NCIT_C2507 label "MKC-1" @default.
- NCIT_C2507 subClassOf NCIT_C186664 @default.
- NCIT_C2507 subClassOf NCIT_C1908 @default.
- NCIT_C2507 subClassOf NCIT_C1909 @default.
- NCIT_C2507 subClassOf NCIT_C2507 @default.
- NCIT_C2507 subClassOf NCIT_C25974 @default.
- NCIT_C2507 subClassOf NCIT_C273 @default.
- NCIT_C2507 subClassOf NCIT_C274 @default.