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- NCIT_C2513 IAO_0000115 "A fusion protein consisting of the Fv portion of a monoclonal antibody attached to a 38-kDa fragment of the Pseudomonas exotoxin A (with amino acids 365-380 deleted). LMB-2 immunotoxin targets the interleukin 2 receptor (also known as IL-2R or CD25) which is expressed on activated normal T and B cells and macrophages and on the cells of various hematologic malignancies. The antibody attaches to the IL-2R on the cell membrane, facilitating the entry of the exotoxin. The exotoxin moiety induces caspase-mediated apoptosis of tumor cells via a mechanism involving mitochondrial damage; it also catalyzes the transfer of ADP ribose from nicotinamide adenine dinucleotide (NAD) to elongation factor-2 in eukaryotic cells, thereby inactivating elongation factor 2 and inhibiting protein synthesis. (NCI04)" @default.
- NCIT_C2513 NCIT_A32 NCIT_C1909 @default.
- NCIT_C2513 NCIT_A7 NCIT_C17073 @default.
- NCIT_C2513 NCIT_A7 NCIT_C38586 @default.
- NCIT_C2513 NCIT_NHC0 "C2513" @default.
- NCIT_C2513 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C2513 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C2513 NCIT_P107 "LMB-2 Immunotoxin" @default.
- NCIT_C2513 NCIT_P108 "LMB-2 Immunotoxin" @default.
- NCIT_C2513 NCIT_P175 "676422" @default.
- NCIT_C2513 NCIT_P207 "C0655013" @default.
- NCIT_C2513 NCIT_P322 "CTRP" @default.
- NCIT_C2513 NCIT_P322 "GDC" @default.
- NCIT_C2513 NCIT_P325 "A toxic substance linked to an antibody that attaches to tumor cells and kills them." @default.
- NCIT_C2513 NCIT_P329 "43377" @default.
- NCIT_C2513 NCIT_P330 "43377" @default.
- NCIT_C2513 NCIT_P366 "LMB-2_Immunotoxin" @default.
- NCIT_C2513 NCIT_P375 "LMB-2 Immunotoxin" @default.
- NCIT_C2513 NCIT_P399 "43377" @default.
- NCIT_C2513 NCIT_R124 NCIT_C16956 @default.
- NCIT_C2513 NCIT_R124 NCIT_C17710 @default.
- NCIT_C2513 NCIT_R124 NCIT_C17828 @default.
- NCIT_C2513 NCIT_R124 NCIT_C18219 @default.
- NCIT_C2513 NCIT_R124 NCIT_C19986 @default.
- NCIT_C2513 NCIT_R124 NCIT_C40474 @default.
- NCIT_C2513 NCIT_R124 NCIT_C45524 @default.
- NCIT_C2513 NCIT_R125 NCIT_C17557 @default.
- NCIT_C2513 NCIT_R125 NCIT_C17710 @default.
- NCIT_C2513 NCIT_R125 NCIT_C17828 @default.
- NCIT_C2513 NCIT_R125 NCIT_C18966 @default.
- NCIT_C2513 NCIT_R125 NCIT_C20480 @default.
- NCIT_C2513 NCIT_R125 NCIT_C21049 @default.
- NCIT_C2513 NCIT_R125 NCIT_C21050 @default.
- NCIT_C2513 NCIT_R125 NCIT_C28498 @default.
- NCIT_C2513 NCIT_R125 NCIT_C29857 @default.
- NCIT_C2513 NCIT_R125 NCIT_C29860 @default.
- NCIT_C2513 NCIT_R125 NCIT_C30022 @default.
- NCIT_C2513 NCIT_R125 NCIT_C41515 @default.
- NCIT_C2513 NCIT_R146 NCIT_C17021 @default.
- NCIT_C2513 NCIT_R146 NCIT_C17073 @default.
- NCIT_C2513 NCIT_R146 NCIT_C17667 @default.
- NCIT_C2513 NCIT_R146 NCIT_C17728 @default.
- NCIT_C2513 NCIT_R146 NCIT_C18106 @default.
- NCIT_C2513 NCIT_R146 NCIT_C20027 @default.
- NCIT_C2513 NCIT_R146 NCIT_C26548 @default.
- NCIT_C2513 NCIT_R146 NCIT_C38576 @default.
- NCIT_C2513 NCIT_R146 NCIT_C38586 @default.
- NCIT_C2513 NCIT_R72 NCIT_C12219 @default.
- NCIT_C2513 NCIT_R72 NCIT_C12474 @default.
- NCIT_C2513 NCIT_R72 NCIT_C12476 @default.
- NCIT_C2513 NCIT_R72 NCIT_C12508 @default.
- NCIT_C2513 NCIT_R72 NCIT_C12535 @default.
- NCIT_C2513 NCIT_R72 NCIT_C12558 @default.
- NCIT_C2513 NCIT_R72 NCIT_C12621 @default.
- NCIT_C2513 NCIT_R72 NCIT_C12657 @default.
- NCIT_C2513 NCIT_R72 NCIT_C21599 @default.
- NCIT_C2513 NCIT_R72 NCIT_C32725 @default.
- NCIT_C2513 NCIT_R72 NCIT_C39567 @default.
- NCIT_C2513 normalizedInformationContent "100" @default.
- NCIT_C2513 referenceCount "1" @default.
- NCIT_C2513 hasExactSynonym "Anti-Tac(Fv)-PE38" @default.
- NCIT_C2513 hasExactSynonym "Humanized AntiTac Toxin" @default.
- NCIT_C2513 hasExactSynonym "Immunotoxin LMB-2" @default.
- NCIT_C2513 hasExactSynonym "LMB-2 (Anti-TAC(FV)-PE-38)" @default.
- NCIT_C2513 hasExactSynonym "LMB-2 Immunotoxin" @default.
- NCIT_C2513 hasExactSynonym "LMB-2 immunotoxin" @default.
- NCIT_C2513 hasExactSynonym "LMB-2" @default.
- NCIT_C2513 inSubset NCIT_C116977 @default.
- NCIT_C2513 inSubset NCIT_C116978 @default.
- NCIT_C2513 inSubset NCIT_C128784 @default.
- NCIT_C2513 inSubset NCIT_C157711 @default.
- NCIT_C2513 inSubset NCIT_C157712 @default.
- NCIT_C2513 inSubset NCIT_C176424 @default.
- NCIT_C2513 inSubset NCIT_C177537 @default.
- NCIT_C2513 type Class @default.
- NCIT_C2513 isDefinedBy ncit.owl @default.
- NCIT_C2513 label "LMB-2 Immunotoxin" @default.
- NCIT_C2513 subClassOf NCIT_C1512 @default.
- NCIT_C2513 subClassOf NCIT_C1908 @default.
- NCIT_C2513 subClassOf NCIT_C1909 @default.
- NCIT_C2513 subClassOf NCIT_C2513 @default.
- NCIT_C2513 subClassOf NCIT_C307 @default.
- NCIT_C2513 subClassOf NCIT_C308 @default.
- NCIT_C2513 subClassOf NCIT_C575 @default.
- NCIT_C2513 subClassOf NCIT_C78532 @default.
- NCIT_C2513 equivalentClass B48e9bb0bb747273d603ff4da6fb6673e @default.
- NCIT_C2513 equivalentClass Bfac0eb2ed4637e2fe13edf1bb72067f1 @default.