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- NCIT_C2570 IAO_0000115 "A compound composed of the short chain fatty acid (SCFA) butyrate combined with the amino acid arginine, with potential Epstein-Barr virus thymidine kinase gene (EBV-TK)-inducing activity. Upon administration, arginine butyrate induces the expression of thymidine kinase (TK). This activates a co-administered antiviral, such as ganciclovir, and results in the destruction of EBV-infected cancer cells. In addition, butyrate inhibits histone deacetylase (HDAC), which results in hyperacetylation of histones H3 and H4. Acetylated histones have a reduced affinity for chromatin; this reduced histone-chromatin affinity may allow chromosomal unfolding, potentially enhancing the expression of genes related to tumor cell growth arrest and apoptosis." @default.
- NCIT_C2570 NCIT_A32 NCIT_C1909 @default.
- NCIT_C2570 NCIT_NHC0 "C2570" @default.
- NCIT_C2570 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C2570 NCIT_P106 "Organic Chemical" @default.
- NCIT_C2570 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C2570 NCIT_P107 "Arginine Butyrate" @default.
- NCIT_C2570 NCIT_P108 "Arginine Butyrate" @default.
- NCIT_C2570 NCIT_P207 "C0052329" @default.
- NCIT_C2570 NCIT_P210 "80407-72-3" @default.
- NCIT_C2570 NCIT_P319 "IK8S1P79MU" @default.
- NCIT_C2570 NCIT_P322 "CTRP" @default.
- NCIT_C2570 NCIT_P322 "FDA" @default.
- NCIT_C2570 NCIT_P322 "GDC" @default.
- NCIT_C2570 NCIT_P325 "A substance that is being studied as a treatment for cancer." @default.
- NCIT_C2570 NCIT_P329 "42492" @default.
- NCIT_C2570 NCIT_P330 "42492" @default.
- NCIT_C2570 NCIT_P350 "3C6H14N4O2.4C4H8O2" @default.
- NCIT_C2570 NCIT_P366 "Arginine_Butyrate" @default.
- NCIT_C2570 NCIT_P375 "Arginine Butyrate" @default.
- NCIT_C2570 NCIT_P375 "Short Chain Fatty Acid HQK-1004" @default.
- NCIT_C2570 NCIT_P399 "42492" @default.
- NCIT_C2570 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C2570 referenceCount "2" @default.
- NCIT_C2570 hasExactSynonym "ARGININE BUTYRATE" @default.
- NCIT_C2570 hasExactSynonym "Arginine Butyrate" @default.
- NCIT_C2570 hasExactSynonym "HQK-1004" @default.
- NCIT_C2570 hasExactSynonym "L-Arginine, Butanoate (3:4)" @default.
- NCIT_C2570 hasExactSynonym "SCFA HQK-1004" @default.
- NCIT_C2570 hasExactSynonym "Short Chain Fatty Acid HQK-1004" @default.
- NCIT_C2570 hasExactSynonym "VX-105" @default.
- NCIT_C2570 hasExactSynonym "arginine butyrate" @default.
- NCIT_C2570 inSubset NCIT_C116977 @default.
- NCIT_C2570 inSubset NCIT_C116978 @default.
- NCIT_C2570 inSubset NCIT_C128784 @default.
- NCIT_C2570 inSubset NCIT_C157711 @default.
- NCIT_C2570 inSubset NCIT_C157712 @default.
- NCIT_C2570 inSubset NCIT_C176424 @default.
- NCIT_C2570 inSubset NCIT_C177537 @default.
- NCIT_C2570 inSubset NCIT_C63923 @default.
- NCIT_C2570 type Class @default.
- NCIT_C2570 isDefinedBy ncit.owl @default.
- NCIT_C2570 label "Arginine Butyrate" @default.
- NCIT_C2570 subClassOf NCIT_C163758 @default.
- NCIT_C2570 subClassOf NCIT_C1908 @default.
- NCIT_C2570 subClassOf NCIT_C1909 @default.
- NCIT_C2570 subClassOf NCIT_C1946 @default.
- NCIT_C2570 subClassOf NCIT_C2570 @default.
- NCIT_C2570 subClassOf NCIT_C274 @default.
- NCIT_C2570 subClassOf NCIT_C471 @default.