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- NCIT_C2571 IAO_0000115 "An antimetabolite and a chlorine derivative of the intracellular secondary messenger, cyclic adenosine 3,5-monophosphate (cAMP), with potential antineoplastic activity. Tocladesine appears to be converted to 8-chloro-adenosine by phosphodiesterases and subsequently phosphorylated to 8-chloro-ATP, which functions as a purine analogue and competes with ATP in transcription. In addition, generation of 8-chloro-ATP depletes endogenous ATP pool that is essential for many biological reactions in intracellular energy transfer. As a result, this agent causes RNA synthesis inhibition, blocks cellular proliferation, and induces apoptosis." @default.
- NCIT_C2571 NCIT_A32 NCIT_C1909 @default.
- NCIT_C2571 NCIT_NHC0 "C2571" @default.
- NCIT_C2571 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C2571 NCIT_P107 "Tocladesine" @default.
- NCIT_C2571 NCIT_P108 "Tocladesine" @default.
- NCIT_C2571 NCIT_P207 "C0050063" @default.
- NCIT_C2571 NCIT_P210 "41941-56-4" @default.
- NCIT_C2571 NCIT_P319 "BQ94Z7E5OR" @default.
- NCIT_C2571 NCIT_P322 "CTRP" @default.
- NCIT_C2571 NCIT_P322 "FDA" @default.
- NCIT_C2571 NCIT_P322 "GDC" @default.
- NCIT_C2571 NCIT_P325 "A substance that is being studied as an anticancer drug. It is an analogue of a substance that occurs naturally in the body (cyclic adenosine monophosphate)." @default.
- NCIT_C2571 NCIT_P329 "42670" @default.
- NCIT_C2571 NCIT_P330 "42670" @default.
- NCIT_C2571 NCIT_P350 "C10H11ClN5O6P" @default.
- NCIT_C2571 NCIT_P366 "Tocladesine" @default.
- NCIT_C2571 NCIT_P375 "Tocladesine" @default.
- NCIT_C2571 NCIT_P399 "42670" @default.
- NCIT_C2571 normalizedInformationContent "100" @default.
- NCIT_C2571 referenceCount "1" @default.
- NCIT_C2571 hasExactSynonym "8-Chloro Cyclic AMP" @default.
- NCIT_C2571 hasExactSynonym "8-Chloroadenosine Cyclic 3':5'-Monophosphate" @default.
- NCIT_C2571 hasExactSynonym "8-Cl-cAMP" @default.
- NCIT_C2571 hasExactSynonym "Adenazole" @default.
- NCIT_C2571 hasExactSynonym "TOCLADESINE" @default.
- NCIT_C2571 hasExactSynonym "Tocladesine" @default.
- NCIT_C2571 hasExactSynonym "tocladesine" @default.
- NCIT_C2571 inSubset NCIT_C116977 @default.
- NCIT_C2571 inSubset NCIT_C116978 @default.
- NCIT_C2571 inSubset NCIT_C128784 @default.
- NCIT_C2571 inSubset NCIT_C157711 @default.
- NCIT_C2571 inSubset NCIT_C157712 @default.
- NCIT_C2571 inSubset NCIT_C176424 @default.
- NCIT_C2571 inSubset NCIT_C177537 @default.
- NCIT_C2571 inSubset NCIT_C63923 @default.
- NCIT_C2571 type Class @default.
- NCIT_C2571 isDefinedBy ncit.owl @default.
- NCIT_C2571 label "Tocladesine" @default.
- NCIT_C2571 subClassOf NCIT_C1556 @default.
- NCIT_C2571 subClassOf NCIT_C186664 @default.
- NCIT_C2571 subClassOf NCIT_C1908 @default.
- NCIT_C2571 subClassOf NCIT_C1909 @default.
- NCIT_C2571 subClassOf NCIT_C1934 @default.
- NCIT_C2571 subClassOf NCIT_C2122 @default.
- NCIT_C2571 subClassOf NCIT_C2571 @default.
- NCIT_C2571 subClassOf NCIT_C272 @default.
- NCIT_C2571 subClassOf NCIT_C274 @default.