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- NCIT_C2593 IAO_0000115 "The cytoplasmic domain or intracellular domain (ICD) of the HER2/neu protein that exhibits tyrosine kinase activity. Based on sensitization theory, co-administration of trastuzumab (anti-HER-2/neu monoclonal antibody) and HER-2/neu intracellular domain protein may result in the potentiation of a HER2/neu-specific cytotoxic T lymphocyte (CTL) response against tumor cells overexpressing the HER2/neu protein. HER-2/neu protein, a glycoprotein cell surface receptor that is composed of an extracellular domain (ECD), a transmembrane domain, and an ICD, is overexpressed by many adenocarcinomas including breast adenocarcinoma." @default.
- NCIT_C2593 NCIT_A13 NCIT_C17756 @default.
- NCIT_C2593 NCIT_A7 NCIT_C17319 @default.
- NCIT_C2593 NCIT_NHC0 "C2593" @default.
- NCIT_C2593 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C2593 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C2593 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C2593 NCIT_P107 "HER-2/neu Intracellular Domain Protein" @default.
- NCIT_C2593 NCIT_P108 "HER-2/neu Intracellular Domain Protein" @default.
- NCIT_C2593 NCIT_P207 "C3146228" @default.
- NCIT_C2593 NCIT_P322 "CTRP" @default.
- NCIT_C2593 NCIT_P329 "38047" @default.
- NCIT_C2593 NCIT_P330 "38047" @default.
- NCIT_C2593 NCIT_P366 "HER-2_neu_Intracellular_Domain_Protein" @default.
- NCIT_C2593 NCIT_P399 "38047" @default.
- NCIT_C2593 normalizedInformationContent "100" @default.
- NCIT_C2593 referenceCount "1" @default.
- NCIT_C2593 hasExactSynonym "HER-2 ICD Peptide" @default.
- NCIT_C2593 hasExactSynonym "HER-2/neu ICD Protein" @default.
- NCIT_C2593 hasExactSynonym "HER-2/neu Intracellular Domain Protein" @default.
- NCIT_C2593 hasExactSynonym "HER2 ICD" @default.
- NCIT_C2593 hasExactSynonym "HER2 Intracellular Domain" @default.
- NCIT_C2593 inSubset NCIT_C116977 @default.
- NCIT_C2593 inSubset NCIT_C116978 @default.
- NCIT_C2593 inSubset NCIT_C128784 @default.
- NCIT_C2593 inSubset NCIT_C142799 @default.
- NCIT_C2593 inSubset NCIT_C142800 @default.
- NCIT_C2593 inSubset NCIT_C176424 @default.
- NCIT_C2593 type Class @default.
- NCIT_C2593 isDefinedBy ncit.owl @default.
- NCIT_C2593 label "HER-2/neu Intracellular Domain Protein" @default.
- NCIT_C2593 subClassOf NCIT_C1908 @default.
- NCIT_C2593 subClassOf NCIT_C1909 @default.
- NCIT_C2593 subClassOf NCIT_C2593 @default.
- NCIT_C2593 subClassOf NCIT_C268 @default.
- NCIT_C2593 subClassOf NCIT_C307 @default.
- NCIT_C2593 subClassOf NCIT_C912 @default.