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- NCIT_C25977 IAO_0000115 "Suppressor of Cytokine Signaling (SOCS/SSI) Family Genes encode cytokine-specific-inducible negative feedback regulators that function downstream of cytokine receptors to attenuate signal transduction. Suppressor of Cytokine Signaling Proteins contain SH2 and SOCS BOX domains and are implicated, through SOCS box binding, in ubiquitin-dependent protein degradation. SOCS proteins interact with multiple tyrosine kinase activated signaling proteins and inhibit cytokine signal transduction by binding to tyrosine kinase receptors. SOCS proteins regulate cell growth and survival, placental development, hematopoiesis, and T-cell allergic responses. (NCI)" @default.
- NCIT_C25977 NCIT_NHC0 "C25977" @default.
- NCIT_C25977 NCIT_P106 "Gene or Genome" @default.
- NCIT_C25977 NCIT_P108 "Suppressor of Cytokine Signaling Family Gene" @default.
- NCIT_C25977 NCIT_P207 "C1336533" @default.
- NCIT_C25977 NCIT_P366 "Suppressor_of_Cytokine_Signaling_Family_Gene" @default.
- NCIT_C25977 NCIT_P96 "Suppressor of Cytokine Signaling Family Protein" @default.
- NCIT_C25977 NCIT_R37 NCIT_C17133 @default.
- NCIT_C25977 NCIT_R37 NCIT_C17828 @default.
- NCIT_C25977 NCIT_R37 NCIT_C19143 @default.
- NCIT_C25977 NCIT_R37 NCIT_C20480 @default.
- NCIT_C25977 NCIT_R37 NCIT_C21124 @default.
- NCIT_C25977 NCIT_R37 NCIT_C25976 @default.
- NCIT_C25977 NCIT_R41 NCIT_C14182 @default.
- NCIT_C25977 NCIT_R41 NCIT_C14225 @default.
- NCIT_C25977 NCIT_R41 NCIT_C14234 @default.
- NCIT_C25977 NCIT_R41 NCIT_C14250 @default.
- NCIT_C25977 NCIT_R41 NCIT_C14262 @default.
- NCIT_C25977 NCIT_R41 NCIT_C14282 @default.
- NCIT_C25977 NCIT_R41 NCIT_C25796 @default.
- NCIT_C25977 NCIT_R41 NCIT_C79740 @default.
- NCIT_C25977 normalizedInformationContent "82.536929774922015" @default.
- NCIT_C25977 referenceCount "14" @default.
- NCIT_C25977 hasExactSynonym "CIS Family Gene" @default.
- NCIT_C25977 hasExactSynonym "Cytokine-Induced STAT Inhibitor Family Gene" @default.
- NCIT_C25977 hasExactSynonym "SOCS Family Gene" @default.
- NCIT_C25977 hasExactSynonym "SSI Family Gene" @default.
- NCIT_C25977 hasExactSynonym "STAT-Induced STAT Inhibitor Family Gene" @default.
- NCIT_C25977 hasExactSynonym "Suppressor of Cytokine Signaling Family Gene" @default.
- NCIT_C25977 type Class @default.
- NCIT_C25977 isDefinedBy ncit.owl @default.
- NCIT_C25977 label "Suppressor of Cytokine Signaling Family Gene" @default.
- NCIT_C25977 subClassOf B190a1d46c32b8011d68888faa5eaae52 @default.
- NCIT_C25977 subClassOf B1b9501b7dc0140536679a06ad10ac4d6 @default.
- NCIT_C25977 subClassOf Bbc4b42a0394621a2ab9df870667c59a9 @default.
- NCIT_C25977 subClassOf Bcc0cec61624bfcba5cd9ac14126ae0ee @default.
- NCIT_C25977 subClassOf NCIT_C16612 @default.
- NCIT_C25977 subClassOf NCIT_C20921 @default.
- NCIT_C25977 subClassOf NCIT_C25977 @default.