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- NCIT_C25981 IAO_0000115 "Membrane-Associated Guanylate Kinase Family Genes encode MAGUK (Membrane-Associated GUanylate Kinase homolog) proteins containing DHR, SH3, and C-terminal GK-like domains. MAGUKs include Drosophila lethal(1)discs large-1 tumor suppressor protein (dlg1); mammalian Zo-1 tight junction protein; mammalian synaptic proteins that seem to interact with the cytoplasmic tail of NMDA receptor subunits (SAP90/PSD-95, CHAPSYN-110/PSD-93, SAP97/DLG1 and SAP102); 55 kD erythrocyte membrane protein (p55); C. elegans lin-2 protein; rat CASK protein; and human DLG2 and DLG3 proteins. An N-terminal ATP-binding site (P-loop) of Guanylate Kinase is not conserved in the MAGUK GK-like domain; MAGUKs do retain residues known in GK to bind GMP. (NCI)" @default.
- NCIT_C25981 NCIT_NHC0 "C25981" @default.
- NCIT_C25981 NCIT_P106 "Gene or Genome" @default.
- NCIT_C25981 NCIT_P108 "Membrane-Associated Guanylate Kinase Family Gene" @default.
- NCIT_C25981 NCIT_P207 "C1334692" @default.
- NCIT_C25981 NCIT_P366 "Membrane-Associated_Guanylate_Kinase_Family_Gene" @default.
- NCIT_C25981 NCIT_P98 "Members of membrane-associated guanylate kinase (MAGUK) gene family encode a guanylate kinase (GUK) domain with a catalytically inactive P-loop, which cannot bind ATP. It is thought that MAGUKs use their GUK domain to interact with cytoskeletal proteins and signaling molecules. (HGNC)" @default.
- NCIT_C25981 NCIT_R37 NCIT_C17828 @default.
- NCIT_C25981 NCIT_R37 NCIT_C18081 @default.
- NCIT_C25981 NCIT_R37 NCIT_C20480 @default.
- NCIT_C25981 NCIT_R41 NCIT_C14182 @default.
- NCIT_C25981 NCIT_R41 NCIT_C14225 @default.
- NCIT_C25981 NCIT_R41 NCIT_C14234 @default.
- NCIT_C25981 NCIT_R41 NCIT_C14250 @default.
- NCIT_C25981 NCIT_R41 NCIT_C14262 @default.
- NCIT_C25981 NCIT_R41 NCIT_C14282 @default.
- NCIT_C25981 NCIT_R41 NCIT_C25796 @default.
- NCIT_C25981 NCIT_R41 NCIT_C79740 @default.
- NCIT_C25981 normalizedInformationContent "77.066663625307044" @default.
- NCIT_C25981 referenceCount "32" @default.
- NCIT_C25981 hasExactSynonym "MAGUK Family Gene" @default.
- NCIT_C25981 hasExactSynonym "Membrane-Associated Guanylate Kinase Family Gene" @default.
- NCIT_C25981 type Class @default.
- NCIT_C25981 isDefinedBy ncit.owl @default.
- NCIT_C25981 label "Membrane-Associated Guanylate Kinase Family Gene" @default.
- NCIT_C25981 subClassOf B50d21bc49219eca534ea70b8eb12de07 @default.
- NCIT_C25981 subClassOf B9ae849b8569da642221916ae559a226d @default.
- NCIT_C25981 subClassOf NCIT_C16612 @default.
- NCIT_C25981 subClassOf NCIT_C20194 @default.
- NCIT_C25981 subClassOf NCIT_C25981 @default.