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- NCIT_C2611 IAO_0000115 "An immunotoxin of monoclonal antibody (MoAb) RFB4 covalently linked to a single deglycosylated ricin toxin A-chain (dgA), originated from castor beans. MoAb RFB4 recognizes CD22 antigen, a B-cell adhesion protein expressed on malignant cells in about 70 percent of non-Hodgkin lymphoma and chronic lymphocytic leukemia. Ricin toxin A-chain, a potent protein synthesis inhibitor, was deglycosylated and was used in this immunoconjugate to avoid hepatic entrapment. This agent limits specific cytotoxicity of ricin toxin to CD22-positive malignant cells." @default.
- NCIT_C2611 NCIT_NHC0 "C2611" @default.
- NCIT_C2611 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C2611 NCIT_P108 "Monoclonal Antibody Mono-dgA-RFB4" @default.
- NCIT_C2611 NCIT_P207 "C0935906" @default.
- NCIT_C2611 NCIT_P329 "38178" @default.
- NCIT_C2611 NCIT_P330 "38178" @default.
- NCIT_C2611 NCIT_P366 "Monoclonal_Antibody_Mono-dgA-RFB4" @default.
- NCIT_C2611 NCIT_P399 "38178" @default.
- NCIT_C2611 normalizedInformationContent "100" @default.
- NCIT_C2611 referenceCount "1" @default.
- NCIT_C2611 hasExactSynonym "MONO dgA RFB4" @default.
- NCIT_C2611 hasExactSynonym "Monoclonal Antibody Mono-dgA-RFB4" @default.
- NCIT_C2611 inSubset NCIT_C176424 @default.
- NCIT_C2611 type Class @default.
- NCIT_C2611 isDefinedBy ncit.owl @default.
- NCIT_C2611 label "Monoclonal Antibody Mono-dgA-RFB4" @default.
- NCIT_C2611 subClassOf NCIT_C1512 @default.
- NCIT_C2611 subClassOf NCIT_C1908 @default.
- NCIT_C2611 subClassOf NCIT_C1909 @default.
- NCIT_C2611 subClassOf NCIT_C2002 @default.
- NCIT_C2611 subClassOf NCIT_C2359 @default.
- NCIT_C2611 subClassOf NCIT_C2611 @default.
- NCIT_C2611 subClassOf NCIT_C307 @default.
- NCIT_C2611 subClassOf NCIT_C308 @default.
- NCIT_C2611 subClassOf NCIT_C575 @default.