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- NCIT_C26118 IAO_0000115 "Phosphotyrosine binding (PTB) domains are 100-150 residue modules that commonly bind Asn-Pro-X-Tyr motifs. The PTB domains of the docking proteins Shc and IRS-1 require ligand phosphorylation on the tyrosine residue (NPXpY) for binding. More N-terminal sequences are also required for high affinity binding and conferring specificity. The peptide binds as a b-strand to an anti-parallel b-sheet, while the NPXpY motif makes a turn, positioning the pY for recognition by basic residues. The PTB domains of proteins such as X11, Dab, Fe65 and Numb apparently recognize NPXY or related peptide motifs, but are not dependent on ligand phosphorylation. In addition, the Numb PTB domain can bind an unrelated peptide that forms a helical turn." @default.
- NCIT_C26118 NCIT_NHC0 "C26118" @default.
- NCIT_C26118 NCIT_P106 "Amino Acid Sequence" @default.
- NCIT_C26118 NCIT_P108 "PTB Domain" @default.
- NCIT_C26118 NCIT_P207 "C1518827" @default.
- NCIT_C26118 NCIT_P366 "PTB_Domain" @default.
- NCIT_C26118 normalizedInformationContent "80.873941456936294" @default.
- NCIT_C26118 referenceCount "18" @default.
- NCIT_C26118 hasExactSynonym "PID Domain" @default.
- NCIT_C26118 hasExactSynonym "PID" @default.
- NCIT_C26118 hasExactSynonym "PTB Domain" @default.
- NCIT_C26118 hasExactSynonym "PTB" @default.
- NCIT_C26118 hasExactSynonym "Phosphotyrosine Binding Domain" @default.
- NCIT_C26118 hasExactSynonym "Phosphotyrosine Interaction Domain" @default.
- NCIT_C26118 type Class @default.
- NCIT_C26118 isDefinedBy ncit.owl @default.
- NCIT_C26118 label "PTB Domain" @default.
- NCIT_C26118 subClassOf NCIT_C12219 @default.
- NCIT_C26118 subClassOf NCIT_C13303 @default.
- NCIT_C26118 subClassOf NCIT_C13379 @default.
- NCIT_C26118 subClassOf NCIT_C13426 @default.
- NCIT_C26118 subClassOf NCIT_C13671 @default.
- NCIT_C26118 subClassOf NCIT_C14134 @default.
- NCIT_C26118 subClassOf NCIT_C21599 @default.
- NCIT_C26118 subClassOf NCIT_C26118 @default.