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- NCIT_C2623 IAO_0000115 "A genetically engineered oncolytic virus with potential antineoplastic property. NV1020 is constructed from the herpes simplex virus 1 (HSV-1) by the deletion of a single copy of the gamma (1)34.5 gene and the substitution of the UL23 region of the thymidine kinase (tk) gene with a DNA fragment from HSV-2, thereby resulting in a replication-competent, attenuated virus. This modified virus preferentially transfects rapidly dividing cells, which causes cell lysis in tumor cells. NV1020 has shown reduced virulence against normal tissues and a decreased neurovirulence in comparison with some other modified HSV strains." @default.
- NCIT_C2623 NCIT_A32 NCIT_C1909 @default.
- NCIT_C2623 NCIT_NHC0 "C2623" @default.
- NCIT_C2623 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C2623 NCIT_P106 "Virus" @default.
- NCIT_C2623 NCIT_P107 "NV1020" @default.
- NCIT_C2623 NCIT_P108 "Oncolytic HSV-1 NV1020" @default.
- NCIT_C2623 NCIT_P207 "C0935802" @default.
- NCIT_C2623 NCIT_P322 "CTRP" @default.
- NCIT_C2623 NCIT_P322 "GDC" @default.
- NCIT_C2623 NCIT_P329 "38237" @default.
- NCIT_C2623 NCIT_P330 "38237" @default.
- NCIT_C2623 NCIT_P366 "NV1020" @default.
- NCIT_C2623 NCIT_P375 "Oncolytic HSV-1 NV1020" @default.
- NCIT_C2623 NCIT_P399 "38237" @default.
- NCIT_C2623 normalizedInformationContent "100" @default.
- NCIT_C2623 referenceCount "1" @default.
- NCIT_C2623 hasExactSynonym "NV1020" @default.
- NCIT_C2623 hasExactSynonym "Oncolytic HSV-1 NV1020" @default.
- NCIT_C2623 inSubset NCIT_C116977 @default.
- NCIT_C2623 inSubset NCIT_C116978 @default.
- NCIT_C2623 inSubset NCIT_C128784 @default.
- NCIT_C2623 inSubset NCIT_C157711 @default.
- NCIT_C2623 inSubset NCIT_C157712 @default.
- NCIT_C2623 inSubset NCIT_C176424 @default.
- NCIT_C2623 inSubset NCIT_C177537 @default.
- NCIT_C2623 type Class @default.
- NCIT_C2623 isDefinedBy ncit.owl @default.
- NCIT_C2623 label "Oncolytic HSV-1 NV1020" @default.
- NCIT_C2623 subClassOf NCIT_C129821 @default.
- NCIT_C2623 subClassOf NCIT_C1908 @default.
- NCIT_C2623 subClassOf NCIT_C1909 @default.
- NCIT_C2623 subClassOf NCIT_C2623 @default.
- NCIT_C2623 subClassOf NCIT_C274 @default.
- NCIT_C2623 subClassOf NCIT_C307 @default.
- NCIT_C2623 subClassOf NCIT_C717 @default.