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- NCIT_C26239 IAO_0000115 "Metabotropic glutamate receptor 1 (1194 aa, ~132 kDa) is encoded by the human GRM1 gene. This protein plays a role in in G protein-coupled receptor signal transduction and synaptic transmission." @default.
- NCIT_C26239 NCIT_NHC0 "C26239" @default.
- NCIT_C26239 NCIT_P100 "604473" @default.
- NCIT_C26239 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C26239 NCIT_P106 "Receptor" @default.
- NCIT_C26239 NCIT_P107 "Metabotropic Glutamate Receptor 1" @default.
- NCIT_C26239 NCIT_P108 "Metabotropic Glutamate Receptor 1" @default.
- NCIT_C26239 NCIT_P207 "C0535210" @default.
- NCIT_C26239 NCIT_P322 "CTRP" @default.
- NCIT_C26239 NCIT_P366 "Metabotropic_Glutamate_Receptor-1" @default.
- NCIT_C26239 NCIT_P93 "Q13255" @default.
- NCIT_C26239 NCIT_P98 "L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities." @default.
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- NCIT_C26239 normalizedInformationContent "100" @default.
- NCIT_C26239 referenceCount "1" @default.
- NCIT_C26239 hasExactSynonym "GRM1" @default.
- NCIT_C26239 hasExactSynonym "GRM1-Alpha" @default.
- NCIT_C26239 hasExactSynonym "MGLUR1-Alpha" @default.
- NCIT_C26239 hasExactSynonym "Metabotropic Glutamate Receptor 1" @default.
- NCIT_C26239 hasExactSynonym "mGluR1" @default.
- NCIT_C26239 inSubset NCIT_C116977 @default.
- NCIT_C26239 inSubset NCIT_C142799 @default.
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- NCIT_C26239 type Class @default.
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- NCIT_C26239 label "Metabotropic Glutamate Receptor 1" @default.
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