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- NCIT_C2631 IAO_0000115 "A liposome-encapsulated formulation of paclitaxel, a taxoid compound extracted from the Pacific yew tree Taxus brevifolia, with antineoplastic property. Paclitaxel binds to tubulin and interferes with the assembly/disassembly dynamics of microtubules, thereby resulting in the inhibition of cell division. This agent also induces apoptosis via inactivation of the apoptosis inhibitor, B-cell Leukemia 2 (Bcl-2) protein. Paclitaxel liposome formulation potentially enhances delivery of higher doses of paclitaxel to the target tissues and exhibits lower systemic toxicity." @default.
- NCIT_C2631 NCIT_A32 NCIT_C1909 @default.
- NCIT_C2631 NCIT_A7 NCIT_C17219 @default.
- NCIT_C2631 NCIT_NHC0 "C2631" @default.
- NCIT_C2631 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C2631 NCIT_P108 "Paclitaxel Liposome" @default.
- NCIT_C2631 NCIT_P207 "C0935868" @default.
- NCIT_C2631 NCIT_P322 "GDC" @default.
- NCIT_C2631 NCIT_P325 "A form of the anticancer drug paclitaxel that is contained in very tiny, fat-like particles. It may have fewer side effects and work better than paclitaxel. It is being studied in the treatment of several types of cancer. Paclitaxel liposome blocks the ability of cells to divide and may kill cancer cells. It is a type of mitotic inhibitor and a type of antimicrotubule agent." @default.
- NCIT_C2631 NCIT_P329 "38323" @default.
- NCIT_C2631 NCIT_P330 "38323" @default.
- NCIT_C2631 NCIT_P366 "Paclitaxel_Liposome" @default.
- NCIT_C2631 NCIT_P375 "Paclitaxel Liposome" @default.
- NCIT_C2631 NCIT_P399 "38323" @default.
- NCIT_C2631 NCIT_R124 NCIT_C17828 @default.
- NCIT_C2631 NCIT_R124 NCIT_C20480 @default.
- NCIT_C2631 NCIT_R124 NCIT_C40795 @default.
- NCIT_C2631 NCIT_R124 NCIT_C40798 @default.
- NCIT_C2631 normalizedInformationContent "100" @default.
- NCIT_C2631 referenceCount "1" @default.
- NCIT_C2631 hasExactSynonym "LEP-ETU" @default.
- NCIT_C2631 hasExactSynonym "LipoTaxen" @default.
- NCIT_C2631 hasExactSynonym "Liposome-Encapsulated Paclitaxel" @default.
- NCIT_C2631 hasExactSynonym "PNU-93914" @default.
- NCIT_C2631 hasExactSynonym "Paclitaxel Liposome" @default.
- NCIT_C2631 hasExactSynonym "liposomal paclitaxel" @default.
- NCIT_C2631 hasExactSynonym "paclitaxel liposome" @default.
- NCIT_C2631 inSubset NCIT_C128784 @default.
- NCIT_C2631 inSubset NCIT_C157711 @default.
- NCIT_C2631 inSubset NCIT_C157712 @default.
- NCIT_C2631 inSubset NCIT_C176424 @default.
- NCIT_C2631 inSubset NCIT_C177537 @default.
- NCIT_C2631 type Class @default.
- NCIT_C2631 isDefinedBy ncit.owl @default.
- NCIT_C2631 label "Paclitaxel Liposome" @default.
- NCIT_C2631 subClassOf NCIT_C186664 @default.
- NCIT_C2631 subClassOf NCIT_C1908 @default.
- NCIT_C2631 subClassOf NCIT_C1909 @default.
- NCIT_C2631 subClassOf NCIT_C25974 @default.
- NCIT_C2631 subClassOf NCIT_C2631 @default.
- NCIT_C2631 subClassOf NCIT_C273 @default.
- NCIT_C2631 subClassOf NCIT_C274 @default.
- NCIT_C2631 subClassOf NCIT_C61078 @default.
- NCIT_C2631 subClassOf NCIT_C67437 @default.