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- NCIT_C26339 IAO_0000115 "Tyrosine-protein phosphatase non-receptor type 1 (435 aa, ~50 kDa) is encoded by the human PTPN1 gene. This protein plays a role in endocytosis, the unfolded protein response, signaling and protein dephosphorylation." @default.
- NCIT_C26339 NCIT_NHC0 "C26339" @default.
- NCIT_C26339 NCIT_P100 "176885" @default.
- NCIT_C26339 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C26339 NCIT_P106 "Enzyme" @default.
- NCIT_C26339 NCIT_P107 "Tyrosine-Protein Phosphatase Non-Receptor Type 1" @default.
- NCIT_C26339 NCIT_P108 "Tyrosine-Protein Phosphatase Non-Receptor Type 1" @default.
- NCIT_C26339 NCIT_P207 "C1335056" @default.
- NCIT_C26339 NCIT_P322 "CTRP" @default.
- NCIT_C26339 NCIT_P366 "Non-Receptor_Type_1_Protein_Tyrosine_Phosphatase" @default.
- NCIT_C26339 NCIT_P93 "P18031" @default.
- NCIT_C26339 NCIT_P98 "PTPN1 may dephosphorylate EGFR kinase, as well as JAK2 and TYK2 kinases, suggesting a role in cell growth control, and cell response to interferon stimulation. Oxidation of Cys-215 forms a 4-amino-3-isothiazolidinone serine cross-link, triggering a conformational change that inhibits substrate binding and activity; the active site is restored by reduction. (UniProt)" @default.
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- NCIT_C26339 hasExactSynonym "EC 3.1.3.48" @default.
- NCIT_C26339 hasExactSynonym "PTP-1B" @default.
- NCIT_C26339 hasExactSynonym "PTPN1" @default.
- NCIT_C26339 hasExactSynonym "Protein Tyrosine Phosphatase, Non-Receptor Type 1" @default.
- NCIT_C26339 hasExactSynonym "Protein-Tyrosine Phosphatase 1B" @default.
- NCIT_C26339 hasExactSynonym "Tyrosine-Protein Phosphatase Non-Receptor Type 1" @default.
- NCIT_C26339 inSubset NCIT_C116977 @default.
- NCIT_C26339 inSubset NCIT_C142799 @default.
- NCIT_C26339 inSubset NCIT_C142800 @default.
- NCIT_C26339 type Class @default.
- NCIT_C26339 isDefinedBy ncit.owl @default.
- NCIT_C26339 label "Tyrosine-Protein Phosphatase Non-Receptor Type 1" @default.
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