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- NCIT_C26347 IAO_0000115 "Lymphocyte cytosolic protein 2 (533 aa, ~60 kDa) is encoded by the human LCP2 gene. This protein is involved in signal transduction." @default.
- NCIT_C26347 NCIT_NHC0 "C26347" @default.
- NCIT_C26347 NCIT_P100 "601603" @default.
- NCIT_C26347 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C26347 NCIT_P106 "Biologically Active Substance" @default.
- NCIT_C26347 NCIT_P108 "Lymphocyte Cytosolic Protein 2" @default.
- NCIT_C26347 NCIT_P207 "C1743669" @default.
- NCIT_C26347 NCIT_P366 "Lymphocyte_Cytosolic_Protein-2" @default.
- NCIT_C26347 NCIT_P93 "Q13094" @default.
- NCIT_C26347 NCIT_P98 "Encoded by human LCP2 Gene and expressed in peripheral leukocytes, spleen, thymus, T-cells, B-cells, and monocytes, modular 533-amino acid 76-kD adaptor/scaffold Lymphocyte Cytosolic Protein 2 contains three domains; a PEST domain and phosphorylatable tyrosine residues in the acidic N-terminus, a GRB2 binding site in the central proline-rich domain, and a C-terminal SH2 domain. SLP-76 associates constitutively or inducibly with GRB2 and FYB adapter proteins and with ZAP70 and SYK as a substrate. By supporting receptor-mediated signal transduction, SLP-76 promotes thymic development and T-cell development and activation, as well as mast cell and platelet function. SLP-76 may collect all pre-TCR signals that drive thymocyte development and appears required for separate development of lymphatic vessels from blood vessels. (from LocusLink, Swiss-Prot, OMIM, and NCI)" @default.
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- NCIT_C26347 normalizedInformationContent "100" @default.
- NCIT_C26347 referenceCount "1" @default.
- NCIT_C26347 hasExactSynonym "76 kD Tyrosine Phosphoprotein" @default.
- NCIT_C26347 hasExactSynonym "LCP2 Protein" @default.
- NCIT_C26347 hasExactSynonym "LCP2" @default.
- NCIT_C26347 hasExactSynonym "Lymphocyte Cytosolic Protein 2" @default.
- NCIT_C26347 hasExactSynonym "SH2 Domain-Containing Leukocyte Protein, 76kD" @default.
- NCIT_C26347 hasExactSynonym "SH2 domain-containing leukocyte protein of 76kD" @default.
- NCIT_C26347 hasExactSynonym "SLP-76 Tyrosine Phosphoprotein" @default.
- NCIT_C26347 hasExactSynonym "SLP-76" @default.
- NCIT_C26347 hasExactSynonym "SLP76" @default.
- NCIT_C26347 type Class @default.
- NCIT_C26347 isDefinedBy ncit.owl @default.
- NCIT_C26347 label "Lymphocyte Cytosolic Protein 2" @default.
- NCIT_C26347 subClassOf NCIT_C16725 @default.
- NCIT_C26347 subClassOf NCIT_C17021 @default.
- NCIT_C26347 subClassOf NCIT_C18515 @default.
- NCIT_C26347 subClassOf NCIT_C20027 @default.
- NCIT_C26347 subClassOf NCIT_C26231 @default.
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- NCIT_C26347 subClassOf NCIT_C26548 @default.
- NCIT_C26347 equivalentClass B47d0045c010d9e199014523684ddabbe @default.
- NCIT_C26347 equivalentClass B7c3aff57d9bfd55e14adf09fbd7b80b6 @default.