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- NCIT_C2639 IAO_0000115 "A synthetic broad-spectrum antimicrobial with antibacterial, antifungal, anticoagulant, and potential antiangiogenic activities. Taurolidine, derived from the amino acid taurine, binds to and neutralizes bacterial exotoxins and endotoxins, or lipopolysaccharides (LPS). Taurolidine binding to LPS prevents bacterial adherence to host epithelial cells, thereby prevents bacterial invasion of uninfected host cells. Although the mechanism underlying its antineoplastic activity has not been fully elucidated, it may be related to this agent's anti-adherence property. In addition, taurolidine also promotes apoptosis by inducing various apoptotic factors and suppresses the production of vascular endothelial growth factor (VEGF), a protein that plays an important role in angiogenesis." @default.
- NCIT_C2639 NCIT_A32 NCIT_C1909 @default.
- NCIT_C2639 NCIT_NHC0 "C2639" @default.
- NCIT_C2639 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C2639 NCIT_P108 "Taurolidine" @default.
- NCIT_C2639 NCIT_P207 "C0144567" @default.
- NCIT_C2639 NCIT_P210 "19388-87-5" @default.
- NCIT_C2639 NCIT_P302 "Bronchiectasis; Catheter-Related Sepsis; Otitis Media; Peritonitis; Thoracic Empyema" @default.
- NCIT_C2639 NCIT_P319 "8OBZ1M4V3V" @default.
- NCIT_C2639 NCIT_P322 "FDA" @default.
- NCIT_C2639 NCIT_P322 "GDC" @default.
- NCIT_C2639 NCIT_P325 "A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called anti-infectives." @default.
- NCIT_C2639 NCIT_P329 "38354" @default.
- NCIT_C2639 NCIT_P330 "38354" @default.
- NCIT_C2639 NCIT_P350 "C7H16N4O4S2" @default.
- NCIT_C2639 NCIT_P366 "Taurolidine" @default.
- NCIT_C2639 NCIT_P375 "Taurolidine" @default.
- NCIT_C2639 NCIT_P399 "38354" @default.
- NCIT_C2639 normalizedInformationContent "100" @default.
- NCIT_C2639 referenceCount "1" @default.
- NCIT_C2639 hasExactSynonym "Bis(1,1-dioxoperhydro-1,2,4-thiadiazinyl-4)-methane" @default.
- NCIT_C2639 hasExactSynonym "TAUROLIDINE" @default.
- NCIT_C2639 hasExactSynonym "Taurolidine" @default.
- NCIT_C2639 hasExactSynonym "Taurolin" @default.
- NCIT_C2639 hasExactSynonym "taurolidine" @default.
- NCIT_C2639 inSubset NCIT_C128784 @default.
- NCIT_C2639 inSubset NCIT_C157711 @default.
- NCIT_C2639 inSubset NCIT_C157712 @default.
- NCIT_C2639 inSubset NCIT_C176424 @default.
- NCIT_C2639 inSubset NCIT_C177537 @default.
- NCIT_C2639 inSubset NCIT_C63923 @default.
- NCIT_C2639 type Class @default.
- NCIT_C2639 isDefinedBy ncit.owl @default.
- NCIT_C2639 label "Taurolidine" @default.
- NCIT_C2639 subClassOf NCIT_C1908 @default.
- NCIT_C2639 subClassOf NCIT_C1909 @default.
- NCIT_C2639 subClassOf NCIT_C254 @default.
- NCIT_C2639 subClassOf NCIT_C2639 @default.