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- NCIT_C26418 IAO_0000115 "This region represents the germline organization of the T cell receptor beta locus. The beta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During T cell development, the beta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several D and J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Chromosomal abnormalities involving the T-cell receptor beta locus have been associated with T-cell lymphomas. (from LocusLink)" @default.
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- NCIT_C26418 NCIT_NHC0 "C26418" @default.
- NCIT_C26418 NCIT_P100 "186930" @default.
- NCIT_C26418 NCIT_P102 "U66059" @default.
- NCIT_C26418 NCIT_P106 "Gene or Genome" @default.
- NCIT_C26418 NCIT_P107 "T-Cell Receptor Beta Locus" @default.
- NCIT_C26418 NCIT_P108 "T-Cell Receptor Beta Locus" @default.
- NCIT_C26418 NCIT_P207 "C0524891" @default.
- NCIT_C26418 NCIT_P321 "6957" @default.
- NCIT_C26418 NCIT_P322 "CTRP" @default.
- NCIT_C26418 NCIT_P322 "GDC" @default.
- NCIT_C26418 NCIT_P366 "T-Cell_Receptor_Beta_Locus" @default.
- NCIT_C26418 NCIT_P369 "HGNC:12155" @default.
- NCIT_C26418 NCIT_P375 "TRB" @default.
- NCIT_C26418 NCIT_P96 "T-Cell Receptor Beta Chain" @default.
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- NCIT_C26418 normalizedInformationContent "90.826665450122817" @default.
- NCIT_C26418 referenceCount "4" @default.
- NCIT_C26418 hasExactSynonym "T-Cell Receptor Beta Gene" @default.
- NCIT_C26418 hasExactSynonym "T-Cell Receptor Beta Locus" @default.
- NCIT_C26418 hasExactSynonym "TCRB" @default.
- NCIT_C26418 hasExactSynonym "TRB" @default.
- NCIT_C26418 inSubset NCIT_C116977 @default.
- NCIT_C26418 inSubset NCIT_C142799 @default.
- NCIT_C26418 inSubset NCIT_C142800 @default.
- NCIT_C26418 inSubset NCIT_C142801 @default.
- NCIT_C26418 inSubset NCIT_C157711 @default.
- NCIT_C26418 inSubset NCIT_C177537 @default.
- NCIT_C26418 type Class @default.
- NCIT_C26418 isDefinedBy ncit.owl @default.
- NCIT_C26418 label "T-Cell Receptor Beta Locus" @default.
- NCIT_C26418 subClassOf NCIT_C16612 @default.
- NCIT_C26418 subClassOf NCIT_C18017 @default.
- NCIT_C26418 subClassOf NCIT_C25790 @default.
- NCIT_C26418 subClassOf NCIT_C26418 @default.
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