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- NCIT_C2645 IAO_0000115 "A synthetic analog of vitamin D with potential antineoplastic activity. In the liver, doxercalciferol is converted to its biologically active vitamin D metabolites, which control the intestinal absorption of dietary calcium, the tubular reabsorption of calcium by the kidney and, in conjunction with parathyroid hormone (PTH), the mobilization of calcium from the skeleton. Through interaction with specific receptor proteins in target tissues, these vitamin D metabolites act directly on osteoblasts to stimulate skeletal growth, and on the parathyroid glands to suppress PTH synthesis and secretion. This agent has also been shown to inhibit the growth of retinoblastomas, and may exhibit some antiproliferative activity against prostate cancer cells." @default.
- NCIT_C2645 NCIT_A32 NCIT_C1909 @default.
- NCIT_C2645 NCIT_A7 NCIT_C17485 @default.
- NCIT_C2645 NCIT_NHC0 "C2645" @default.
- NCIT_C2645 NCIT_P106 "Organic Chemical" @default.
- NCIT_C2645 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C2645 NCIT_P107 "Doxercalciferol" @default.
- NCIT_C2645 NCIT_P108 "Doxercalciferol" @default.
- NCIT_C2645 NCIT_P207 "C0043668" @default.
- NCIT_C2645 NCIT_P210 "54573-75-0" @default.
- NCIT_C2645 NCIT_P302 "Secondary hyperparathyroidism in end stage renal disease in patients on hemodialysis." @default.
- NCIT_C2645 NCIT_P319 "3DIZ9LF5Y9" @default.
- NCIT_C2645 NCIT_P322 "CTRP" @default.
- NCIT_C2645 NCIT_P322 "FDA" @default.
- NCIT_C2645 NCIT_P322 "GDC" @default.
- NCIT_C2645 NCIT_P325 "A substance being studied in the prevention of recurrent prostate cancer. It is a type of vitamin D analog." @default.
- NCIT_C2645 NCIT_P329 "38406" @default.
- NCIT_C2645 NCIT_P330 "38406" @default.
- NCIT_C2645 NCIT_P350 "C28H44O2" @default.
- NCIT_C2645 NCIT_P366 "Doxercalciferol" @default.
- NCIT_C2645 NCIT_P375 "Doxercalciferol" @default.
- NCIT_C2645 NCIT_P399 "38406" @default.
- NCIT_C2645 normalizedInformationContent "100" @default.
- NCIT_C2645 referenceCount "1" @default.
- NCIT_C2645 hasExactSynonym "(1alpha,3beta,5Z,7E,22E)-9,10-Secoergosta-5,7,10(19),22-tetraene-1,3-diol" @default.
- NCIT_C2645 hasExactSynonym "1-Alpha-Hydroxyvitamin D2" @default.
- NCIT_C2645 hasExactSynonym "DOXERCALCIFEROL" @default.
- NCIT_C2645 hasExactSynonym "Doxercalciferol" @default.
- NCIT_C2645 hasExactSynonym "Hectorol" @default.
- NCIT_C2645 hasExactSynonym "doxercalciferol" @default.
- NCIT_C2645 inSubset NCIT_C116977 @default.
- NCIT_C2645 inSubset NCIT_C116978 @default.
- NCIT_C2645 inSubset NCIT_C128784 @default.
- NCIT_C2645 inSubset NCIT_C157711 @default.
- NCIT_C2645 inSubset NCIT_C157712 @default.
- NCIT_C2645 inSubset NCIT_C176424 @default.
- NCIT_C2645 inSubset NCIT_C177537 @default.
- NCIT_C2645 inSubset NCIT_C63923 @default.
- NCIT_C2645 type Class @default.
- NCIT_C2645 isDefinedBy ncit.owl @default.
- NCIT_C2645 label "Doxercalciferol" @default.
- NCIT_C2645 subClassOf NCIT_C1505 @default.
- NCIT_C2645 subClassOf NCIT_C1908 @default.
- NCIT_C2645 subClassOf NCIT_C2645 @default.
- NCIT_C2645 subClassOf NCIT_C39713 @default.