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- NCIT_C2649 IAO_0000115 "A prodrug comprised of the naturally occurring omega-3 fatty acid docosahexaenoic acid (DHA) covalently conjugated to the anti-microtubule agent paclitaxel. Because tumor cells take up DHA, DHA-paclitaxel is delivered directly to tumor tissue, where the paclitaxel moiety binds to tubulin and inhibits the disassembly of microtubules, thereby resulting in the inhibition of cell division. Paclitaxel also induces apoptosis by binding to and blocking the function of the apoptosis inhibitor protein Bcl-2 (B-cell Leukemia 2). DHA-paclitaxel exhibits improved pharmacokinetic and toxicity profiles when compared to conventional paclitaxel and has demonstrated antineoplastic activity in animal models of cancer. (NCI04)" @default.
- NCIT_C2649 NCIT_A32 NCIT_C1909 @default.
- NCIT_C2649 NCIT_A7 NCIT_C17219 @default.
- NCIT_C2649 NCIT_NHC0 "C2649" @default.
- NCIT_C2649 NCIT_P106 "Organic Chemical" @default.
- NCIT_C2649 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C2649 NCIT_P107 "DHA-Paclitaxel" @default.
- NCIT_C2649 NCIT_P108 "DHA-Paclitaxel" @default.
- NCIT_C2649 NCIT_P175 "28247" @default.
- NCIT_C2649 NCIT_P207 "C1134470" @default.
- NCIT_C2649 NCIT_P210 "73-67-6" @default.
- NCIT_C2649 NCIT_P319 "OJE5810C4F" @default.
- NCIT_C2649 NCIT_P322 "CTRP" @default.
- NCIT_C2649 NCIT_P322 "FDA" @default.
- NCIT_C2649 NCIT_P322 "GDC" @default.
- NCIT_C2649 NCIT_P325 "A combination of DHA (a natural fatty acid) and paclitaxel (an anticancer drug) being studied in the treatment of cancer. It is a type of mitotic inhibitor." @default.
- NCIT_C2649 NCIT_P329 "38414" @default.
- NCIT_C2649 NCIT_P330 "38414" @default.
- NCIT_C2649 NCIT_P366 "DHA-Paclitaxel" @default.
- NCIT_C2649 NCIT_P375 "DHA-Paclitaxel" @default.
- NCIT_C2649 NCIT_P399 "38414" @default.
- NCIT_C2649 NCIT_R124 NCIT_C17828 @default.
- NCIT_C2649 NCIT_R124 NCIT_C20480 @default.
- NCIT_C2649 NCIT_R124 NCIT_C40795 @default.
- NCIT_C2649 NCIT_R124 NCIT_C40798 @default.
- NCIT_C2649 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C2649 referenceCount "2" @default.
- NCIT_C2649 hasExactSynonym "DHA-Paclitaxel" @default.
- NCIT_C2649 hasExactSynonym "DHA-paclitaxel" @default.
- NCIT_C2649 hasExactSynonym "Docosahexaenoic Acid-Paclitaxel conjugate" @default.
- NCIT_C2649 hasExactSynonym "PACLITAXEL DOCOSAHEXAENOIC ACID" @default.
- NCIT_C2649 hasExactSynonym "TXP" @default.
- NCIT_C2649 hasExactSynonym "Taxoprexin" @default.
- NCIT_C2649 inSubset NCIT_C116977 @default.
- NCIT_C2649 inSubset NCIT_C116978 @default.
- NCIT_C2649 inSubset NCIT_C128784 @default.
- NCIT_C2649 inSubset NCIT_C157711 @default.
- NCIT_C2649 inSubset NCIT_C157712 @default.
- NCIT_C2649 inSubset NCIT_C176424 @default.
- NCIT_C2649 inSubset NCIT_C177537 @default.
- NCIT_C2649 inSubset NCIT_C63923 @default.
- NCIT_C2649 type Class @default.
- NCIT_C2649 isDefinedBy ncit.owl @default.
- NCIT_C2649 label "DHA-Paclitaxel" @default.
- NCIT_C2649 subClassOf NCIT_C1490 @default.
- NCIT_C2649 subClassOf NCIT_C186664 @default.
- NCIT_C2649 subClassOf NCIT_C1908 @default.
- NCIT_C2649 subClassOf NCIT_C1909 @default.
- NCIT_C2649 subClassOf NCIT_C1913 @default.
- NCIT_C2649 subClassOf NCIT_C25974 @default.
- NCIT_C2649 subClassOf NCIT_C2649 @default.
- NCIT_C2649 subClassOf NCIT_C273 @default.
- NCIT_C2649 subClassOf NCIT_C274 @default.
- NCIT_C2649 subClassOf NCIT_C552 @default.
- NCIT_C2649 subClassOf NCIT_C616 @default.
- NCIT_C2649 subClassOf NCIT_C67437 @default.
- NCIT_C2649 subClassOf NCIT_C718 @default.
- NCIT_C2649 subClassOf NCIT_C860 @default.