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- NCIT_C2654 IAO_0000115 "A recombinant human immunoglobulin (Ig) G1 monoclonal antibody directed against the human T-cell receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA4), with immune checkpoint inhibitory and antineoplastic activities. Ipilimumab binds to CTLA4 expressed on T-cells and inhibits the CTLA4-mediated downregulation of T-cell activation. This leads to a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells. CTLA4, an inhibitory receptor and member of the immunoglobulin superfamily, plays a key role in the downregulation of the immune system." @default.
- NCIT_C2654 NCIT_A32 NCIT_C1909 @default.
- NCIT_C2654 NCIT_A7 NCIT_C17489 @default.
- NCIT_C2654 NCIT_NHC0 "C2654" @default.
- NCIT_C2654 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C2654 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C2654 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C2654 NCIT_P107 "Ipilimumab" @default.
- NCIT_C2654 NCIT_P108 "Ipilimumab" @default.
- NCIT_C2654 NCIT_P175 "720801" @default.
- NCIT_C2654 NCIT_P175 "732442" @default.
- NCIT_C2654 NCIT_P207 "C1367202" @default.
- NCIT_C2654 NCIT_P210 "477202-00-9" @default.
- NCIT_C2654 NCIT_P302 "Unresectable or Metastatic Melanoma" @default.
- NCIT_C2654 NCIT_P319 "6T8C155666" @default.
- NCIT_C2654 NCIT_P322 "CTRP" @default.
- NCIT_C2654 NCIT_P322 "FDA" @default.
- NCIT_C2654 NCIT_P322 "GDC" @default.
- NCIT_C2654 NCIT_P325 "A monoclonal antibody being studied in the treatment of certain types of cancer. Ipilimumab is made in the laboratory and binds to the molecule CTLA-4 on T cells (a type of white blood cell). Ipilimumab may block CTLA-4 and help the immune system kill cancer cells." @default.
- NCIT_C2654 NCIT_P329 "38447" @default.
- NCIT_C2654 NCIT_P330 "38447" @default.
- NCIT_C2654 NCIT_P366 "Anti-Cytotoxic_T-Lymphocyte-Associated_Antigen-4_Monoclonal_Antibody" @default.
- NCIT_C2654 NCIT_P375 "Ipilimumab" @default.
- NCIT_C2654 NCIT_P399 "38447" @default.
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- NCIT_C2654 NCIT_R72 NCIT_C104083 @default.
- NCIT_C2654 NCIT_R72 NCIT_C12219 @default.
- NCIT_C2654 NCIT_R72 NCIT_C12476 @default.
- NCIT_C2654 NCIT_R72 NCIT_C12508 @default.
- NCIT_C2654 NCIT_R72 NCIT_C12535 @default.
- NCIT_C2654 NCIT_R72 NCIT_C12542 @default.
- NCIT_C2654 NCIT_R72 NCIT_C12543 @default.
- NCIT_C2654 NCIT_R72 NCIT_C21599 @default.
- NCIT_C2654 NCIT_R72 NCIT_C32725 @default.
- NCIT_C2654 NCIT_R72 NCIT_C33061 @default.
- NCIT_C2654 NCIT_R72 NCIT_C38434 @default.
- NCIT_C2654 NCIT_R72 NCIT_C38439 @default.
- NCIT_C2654 NCIT_R72 NCIT_C39567 @default.
- NCIT_C2654 NCIT_R72 NCIT_C39568 @default.
- NCIT_C2654 normalizedInformationContent "83.027314241919257" @default.
- NCIT_C2654 referenceCount "13" @default.
- NCIT_C2654 hasExactSynonym "Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody" @default.
- NCIT_C2654 hasExactSynonym "BMS-734016" @default.
- NCIT_C2654 hasExactSynonym "IPILIMUMAB" @default.
- NCIT_C2654 hasExactSynonym "Ipilimumab Biosimilar CS1002" @default.
- NCIT_C2654 hasExactSynonym "Ipilimumab" @default.
- NCIT_C2654 hasExactSynonym "MDX-010" @default.
- NCIT_C2654 hasExactSynonym "MDX-CTLA4" @default.
- NCIT_C2654 hasExactSynonym "Yervoy" @default.
- NCIT_C2654 hasExactSynonym "ipilimumab" @default.
- NCIT_C2654 inSubset NCIT_C116977 @default.
- NCIT_C2654 inSubset NCIT_C116978 @default.
- NCIT_C2654 inSubset NCIT_C128784 @default.
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- NCIT_C2654 inSubset NCIT_C63923 @default.
- NCIT_C2654 type Class @default.
- NCIT_C2654 isDefinedBy ncit.owl @default.
- NCIT_C2654 label "Ipilimumab" @default.
- NCIT_C2654 subClassOf B36396cf25fa1c83d16be2c9e6838c715 @default.
- NCIT_C2654 subClassOf B455530e0e8b144cab4de4d9a8952d2fb @default.
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- NCIT_C2654 subClassOf NCIT_C307 @default.
- NCIT_C2654 subClassOf NCIT_C308 @default.