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- NCIT_C26555 IAO_0000115 "Generation of Antibody Diversity during B-lymphocyte development results from a cascade of temporally ordered random gene shuffling translocations by a recombinase that join any one of multiple alternative discrete V, D, and J (heavy chain) or V and J (light chain) antibody gene variable region DNA coding segments that produce in each B-lymphocyte an antibody with a unique antigen binding region composed of a heavy and a light protein chain. In addition, splicing inaccuracies or insertion of additional nucleotides at the segment junctions generate further junctional diversity and somatic hypermutation of V regions, as B-lymphocytes proliferate, create better fitting antigen-binding sites." @default.
- NCIT_C26555 NCIT_NHC0 "C26555" @default.
- NCIT_C26555 NCIT_P106 "Molecular Function" @default.
- NCIT_C26555 NCIT_P108 "Generation of Antibody Diversity" @default.
- NCIT_C26555 NCIT_P207 "C1517502" @default.
- NCIT_C26555 NCIT_P366 "Generation_of_Antibody_Diversity" @default.
- NCIT_C26555 NCIT_R35 NCIT_C16399 @default.
- NCIT_C26555 NCIT_R35 NCIT_C17828 @default.
- NCIT_C26555 NCIT_R35 NCIT_C20480 @default.
- NCIT_C26555 NCIT_R35 NCIT_C28391 @default.
- NCIT_C26555 normalizedInformationContent "90.826665450122817" @default.
- NCIT_C26555 referenceCount "4" @default.
- NCIT_C26555 hasExactSynonym "Generation of Antibody Diversity" @default.
- NCIT_C26555 type Class @default.
- NCIT_C26555 isDefinedBy ncit.owl @default.
- NCIT_C26555 label "Generation of Antibody Diversity" @default.
- NCIT_C26555 subClassOf B300265c1b3fe6745a9ab90f385713683 @default.
- NCIT_C26555 subClassOf B3da77406771f3ee25b42e6f808ce3e9e @default.
- NCIT_C26555 subClassOf NCIT_C17828 @default.
- NCIT_C26555 subClassOf NCIT_C17937 @default.
- NCIT_C26555 subClassOf NCIT_C18839 @default.
- NCIT_C26555 subClassOf NCIT_C21124 @default.
- NCIT_C26555 subClassOf NCIT_C26555 @default.