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- NCIT_C2656 IAO_0000115 "The hydrobromide salt of halofuginone, a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibro-proliferative diseases." @default.
- NCIT_C2656 NCIT_A32 NCIT_C1909 @default.
- NCIT_C2656 NCIT_A6 NCIT_C1120 @default.
- NCIT_C2656 NCIT_A7 NCIT_C17592 @default.
- NCIT_C2656 NCIT_A7 NCIT_C20455 @default.
- NCIT_C2656 NCIT_A7 NCIT_C30013 @default.
- NCIT_C2656 NCIT_A7 NCIT_C30015 @default.
- NCIT_C2656 NCIT_NHC0 "C2656" @default.
- NCIT_C2656 NCIT_P106 "Organic Chemical" @default.
- NCIT_C2656 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C2656 NCIT_P107 "Halofuginone Hydrobromide" @default.
- NCIT_C2656 NCIT_P108 "Halofuginone Hydrobromide" @default.
- NCIT_C2656 NCIT_P175 "713205" @default.
- NCIT_C2656 NCIT_P207 "C0521922" @default.
- NCIT_C2656 NCIT_P210 "17395-31-2" @default.
- NCIT_C2656 NCIT_P210 "64924-67-0" @default.
- NCIT_C2656 NCIT_P302 "Scleroderma and Antiprotozoal; Coccidiosis (Vet)." @default.
- NCIT_C2656 NCIT_P319 "PTC2969MV1" @default.
- NCIT_C2656 NCIT_P322 "CTRP" @default.
- NCIT_C2656 NCIT_P322 "FDA" @default.
- NCIT_C2656 NCIT_P322 "GDC" @default.
- NCIT_C2656 NCIT_P325 "A substance that is being studied for its ability to slow the growth of connective tissue and to prevent the growth of new blood vessels that tumors need to grow. It is a type of quinazolinone alkaloid and a type of antiangiogenesis agent." @default.
- NCIT_C2656 NCIT_P329 "38485" @default.
- NCIT_C2656 NCIT_P330 "38485" @default.
- NCIT_C2656 NCIT_P350 "C16H17BrClN3O3.BrH" @default.
- NCIT_C2656 NCIT_P366 "Halofuginone_Hydrobromide" @default.
- NCIT_C2656 NCIT_P375 "Halofuginone Hydrobromide" @default.
- NCIT_C2656 NCIT_P399 "38485" @default.
- NCIT_C2656 normalizedInformationContent "100" @default.
- NCIT_C2656 referenceCount "1" @default.
- NCIT_C2656 hasExactSynonym "HALOFUGINONE HYDROBROMIDE" @default.
- NCIT_C2656 hasExactSynonym "Halofuginone Hydrobromide" @default.
- NCIT_C2656 hasExactSynonym "Halofuginone IV (intravenous)" @default.
- NCIT_C2656 hasExactSynonym "Halofuginone hydrobromide" @default.
- NCIT_C2656 hasExactSynonym "RU 19110" @default.
- NCIT_C2656 hasExactSynonym "Tempostatin" @default.
- NCIT_C2656 hasExactSynonym "halofuginone hydrobromide" @default.
- NCIT_C2656 inSubset NCIT_C116977 @default.
- NCIT_C2656 inSubset NCIT_C116978 @default.
- NCIT_C2656 inSubset NCIT_C128784 @default.
- NCIT_C2656 inSubset NCIT_C157711 @default.
- NCIT_C2656 inSubset NCIT_C157712 @default.
- NCIT_C2656 inSubset NCIT_C176424 @default.
- NCIT_C2656 inSubset NCIT_C177537 @default.
- NCIT_C2656 inSubset NCIT_C63923 @default.
- NCIT_C2656 type Class @default.
- NCIT_C2656 isDefinedBy ncit.owl @default.
- NCIT_C2656 label "Halofuginone Hydrobromide" @default.
- NCIT_C2656 subClassOf NCIT_C1742 @default.
- NCIT_C2656 subClassOf NCIT_C1908 @default.
- NCIT_C2656 subClassOf NCIT_C1909 @default.
- NCIT_C2656 subClassOf NCIT_C1971 @default.
- NCIT_C2656 subClassOf NCIT_C2656 @default.
- NCIT_C2656 subClassOf NCIT_C274 @default.