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- NCIT_C26561 IAO_0000115 "The replication of DNA in eukaryotic cells is carried out by a complex chromosomal replication apparatus. Two of the enzymes that are part of this machinery are DNA polymerase alpha (POLA), the principal replication enzyme, and primase, the enzyme that catalyzes the synthesis of oligoribonucleotide primers on a DNA template; the primers are required by DNA polymerase alpha to initiate DNA synthesis. These 2 proteins form an enzymatic complex Primase, in turn, is a complex of two proteins, a 49kDa subunit and a 58kDa subunit. Mutation of the 58kDa subunit suggests that it is important for initiation, elongation, and counting. (from OMIM and Biochemistry 2002;41:4891-900)" @default.
- NCIT_C26561 NCIT_NHC0 "C26561" @default.
- NCIT_C26561 NCIT_P100 "600741" @default.
- NCIT_C26561 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C26561 NCIT_P108 "Primase Polypeptide 2B" @default.
- NCIT_C26561 NCIT_P200 "Protein_Complex_Subunit" @default.
- NCIT_C26561 NCIT_P203 "Gene_Product_Kind" @default.
- NCIT_C26561 NCIT_P204 "Gene_Product_Plays_Role_In_Biological_Process|DNA_Replication" @default.
- NCIT_C26561 NCIT_P204 "Gene_Product_is_Physical_Part_of|DNA_Primase" @default.
- NCIT_C26561 NCIT_P310 "Retired_Concept" @default.
- NCIT_C26561 normalizedInformationContent "100" @default.
- NCIT_C26561 referenceCount "1" @default.
- NCIT_C26561 hasExactSynonym "PRIM2B" @default.
- NCIT_C26561 hasExactSynonym "Primase Polypeptide 2B" @default.
- NCIT_C26561 hasExactSynonym "Primase, p58 Subunit" @default.
- NCIT_C26561 type Class @default.
- NCIT_C26561 isDefinedBy ncit.owl @default.
- NCIT_C26561 label "Primase Polypeptide 2B" @default.
- NCIT_C26561 subClassOf NCIT_C26561 @default.
- NCIT_C26561 subClassOf NCIT_C28428 @default.
- NCIT_C26561 subClassOf NCIT_C83480 @default.
- NCIT_C26561 deprecated "true" @default.