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- NCIT_C2662 IAO_0000115 "The R-isomer of a synthetic quinoxaline phenoxypropionic acid derivative with proapoptotic and antiproliferative activities. R(+)XK469 selectively inhibits topoisomerase II-beta, blocks activation of MEK/MAPK signaling kinases, stimulates caspases, and upregulates p53-dependent proteins, including cyclins A and B1, thereby arresting cancer cells in the G2/M phase of the cell cycle. Both R(+) and S(-) isomers of this agent are cytotoxic, although the R-isomer is more potent. (NCI05)" @default.
- NCIT_C2662 NCIT_A32 NCIT_C1909 @default.
- NCIT_C2662 NCIT_A7 NCIT_C17802 @default.
- NCIT_C2662 NCIT_NHC0 "C2662" @default.
- NCIT_C2662 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C2662 NCIT_P107 "R(+)XK469" @default.
- NCIT_C2662 NCIT_P108 "Topoisomerase-II-beta Inhibitor Racemic XK469" @default.
- NCIT_C2662 NCIT_P175 "698215" @default.
- NCIT_C2662 NCIT_P207 "C0765292" @default.
- NCIT_C2662 NCIT_P322 "CTRP" @default.
- NCIT_C2662 NCIT_P322 "GDC" @default.
- NCIT_C2662 NCIT_P325 "A substance that is being studied in the treatment of leukemia. It belongs to the family of drugs called topoisomerase inhibitors." @default.
- NCIT_C2662 NCIT_P329 "38517" @default.
- NCIT_C2662 NCIT_P330 "38517" @default.
- NCIT_C2662 NCIT_P366 "XK469" @default.
- NCIT_C2662 NCIT_P375 "Topoisomerase-II-beta Inhibitor Racemic XK469" @default.
- NCIT_C2662 NCIT_P399 "38517" @default.
- NCIT_C2662 normalizedInformationContent "100" @default.
- NCIT_C2662 referenceCount "1" @default.
- NCIT_C2662 hasExactSynonym "2-{4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy}propionic acid" @default.
- NCIT_C2662 hasExactSynonym "Propanoic acid, 2-[4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy]-, (+ )-(R)-" @default.
- NCIT_C2662 hasExactSynonym "R(+)XK469" @default.
- NCIT_C2662 hasExactSynonym "Topoisomerase-II-beta Inhibitor Racemic XK469" @default.
- NCIT_C2662 hasExactSynonym "XK469" @default.
- NCIT_C2662 inSubset NCIT_C116977 @default.
- NCIT_C2662 inSubset NCIT_C116978 @default.
- NCIT_C2662 inSubset NCIT_C128784 @default.
- NCIT_C2662 inSubset NCIT_C157711 @default.
- NCIT_C2662 inSubset NCIT_C157712 @default.
- NCIT_C2662 inSubset NCIT_C176424 @default.
- NCIT_C2662 inSubset NCIT_C177537 @default.
- NCIT_C2662 type Class @default.
- NCIT_C2662 isDefinedBy ncit.owl @default.
- NCIT_C2662 label "Topoisomerase-II-beta Inhibitor Racemic XK469" @default.
- NCIT_C2662 subClassOf NCIT_C129824 @default.
- NCIT_C2662 subClassOf NCIT_C129825 @default.
- NCIT_C2662 subClassOf NCIT_C1748 @default.
- NCIT_C2662 subClassOf NCIT_C1908 @default.
- NCIT_C2662 subClassOf NCIT_C1909 @default.
- NCIT_C2662 subClassOf NCIT_C1968 @default.
- NCIT_C2662 subClassOf NCIT_C2189 @default.
- NCIT_C2662 subClassOf NCIT_C2662 @default.
- NCIT_C2662 subClassOf NCIT_C274 @default.
- NCIT_C2662 subClassOf NCIT_C471 @default.