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- NCIT_C26652 IAO_0000115 "A 20-mer antisense oligonucleotide complementary to a coding region in the mRNA of the R2 small subunit component of human ribonucleotide reductase. GTI-2040 decreases mRNA and protein levels of R2 in vitro and may inhibit tumor cell proliferation in human tumors in vivo. (NCI04)" @default.
- NCIT_C26652 NCIT_A32 NCIT_C1909 @default.
- NCIT_C26652 NCIT_A7 NCIT_C26621 @default.
- NCIT_C26652 NCIT_NHC0 "C26652" @default.
- NCIT_C26652 NCIT_P106 "Nucleic Acid, Nucleoside, or Nucleotide" @default.
- NCIT_C26652 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C26652 NCIT_P107 "GTI-2040" @default.
- NCIT_C26652 NCIT_P108 "Antisense Oligonucleotide GTI-2040" @default.
- NCIT_C26652 NCIT_P175 "722929" @default.
- NCIT_C26652 NCIT_P207 "C1142995" @default.
- NCIT_C26652 NCIT_P210 "236391-66-5" @default.
- NCIT_C26652 NCIT_P319 "5WY0FWR2CF" @default.
- NCIT_C26652 NCIT_P322 "CTRP" @default.
- NCIT_C26652 NCIT_P322 "FDA" @default.
- NCIT_C26652 NCIT_P322 "GDC" @default.
- NCIT_C26652 NCIT_P325 "A substance being studied in the treatment of cancer. It blocks the production of a protein called ribonucleotide reductase, which helps cells make DNA. This may kill cancer cells that need ribonucleotide reductase to grow. It may also make cells more sensitive to anticancer drugs. It is a type of antisense oligonucleotide, and a type of ribonucleotide reductase inhibitor." @default.
- NCIT_C26652 NCIT_P329 "301635" @default.
- NCIT_C26652 NCIT_P330 "301635" @default.
- NCIT_C26652 NCIT_P366 "GTI-2040" @default.
- NCIT_C26652 NCIT_P375 "Antisense Oligonucleotide GTI-2040" @default.
- NCIT_C26652 NCIT_P399 "301635" @default.
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- NCIT_C26652 NCIT_R125 NCIT_C21049 @default.
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- NCIT_C26652 normalizedInformationContent "90.826665450122817" @default.
- NCIT_C26652 referenceCount "4" @default.
- NCIT_C26652 hasExactSynonym "Antisense Oligonucleotide GTI-2040" @default.
- NCIT_C26652 hasExactSynonym "GTI-2040" @default.
- NCIT_C26652 inSubset NCIT_C116977 @default.
- NCIT_C26652 inSubset NCIT_C116978 @default.
- NCIT_C26652 inSubset NCIT_C128784 @default.
- NCIT_C26652 inSubset NCIT_C157711 @default.
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- NCIT_C26652 inSubset NCIT_C63923 @default.
- NCIT_C26652 type Class @default.
- NCIT_C26652 isDefinedBy ncit.owl @default.
- NCIT_C26652 label "Antisense Oligonucleotide GTI-2040" @default.
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- NCIT_C26652 subClassOf NCIT_C307 @default.