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- NCIT_C26653 IAO_0000115 "A synthetic, orally-active quinazoline with potential antineoplastic properties. Lapatinib reversibly blocks phosphorylation of the epidermal growth factor receptor (EGFR), ErbB2, and the Erk-1 and-2 and AKT kinases; it also inhibits cyclin D protein levels in human tumor cell lines and xenografts. EGFR and ErbB2 have been implicated in the growth of various tumor types." @default.
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- NCIT_C26653 NCIT_NHC0 "C26653" @default.
- NCIT_C26653 NCIT_P106 "Organic Chemical" @default.
- NCIT_C26653 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C26653 NCIT_P108 "Lapatinib" @default.
- NCIT_C26653 NCIT_P171 "12214266" @default.
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- NCIT_C26653 NCIT_P322 "FDA" @default.
- NCIT_C26653 NCIT_P322 "GDC" @default.
- NCIT_C26653 NCIT_P325 "A drug used with another anticancer drug to treat breast cancer that is HER2 positive and has advanced or metastasized (spread to other parts of the body) after treatment with other drugs. Lapatinib is also being studied in the treatment of other types of cancer. It is a type of ErbB-2 and EGFR dual tyrosine kinase inhibitor." @default.
- NCIT_C26653 NCIT_P350 "C29H26ClFN4O4S" @default.
- NCIT_C26653 NCIT_P366 "GW572016" @default.
- NCIT_C26653 NCIT_P368 "CHEBI:49603" @default.
- NCIT_C26653 NCIT_P375 "Lapatinib" @default.
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- NCIT_C26653 normalizedInformationContent "85.460608731874885" @default.
- NCIT_C26653 referenceCount "9" @default.
- NCIT_C26653 hasExactSynonym "GSK572016" @default.
- NCIT_C26653 hasExactSynonym "GW 2016" @default.
- NCIT_C26653 hasExactSynonym "GW2016" @default.
- NCIT_C26653 hasExactSynonym "GW572016" @default.
- NCIT_C26653 hasExactSynonym "LAPATINIB" @default.
- NCIT_C26653 hasExactSynonym "Lapatinib" @default.
- NCIT_C26653 hasExactSynonym "lapatinib" @default.
- NCIT_C26653 inSubset NCIT_C128784 @default.
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- NCIT_C26653 type Class @default.
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- NCIT_C26653 label "Lapatinib" @default.
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