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- NCIT_C26655 IAO_0000115 "The hydrochloride salt of the synthetic high-affinity transition-state analogue forodesine. Forodesine binds preferentially to and inhibits purine nucleotide phosphorylase (PNP), resulting in the accumulation of deoxyguanosine triphosphate and the subsequent inhibition of the enzyme ribonucleoside diphosphate reductase and DNA synthesis. This agent selectively causes apoptosis in stimulated or malignant T-lymphocytes. A transition state analogue is a substrate designed to mimic the properties or the geometry of the transition state of reaction." @default.
- NCIT_C26655 NCIT_A32 NCIT_C1909 @default.
- NCIT_C26655 NCIT_A6 NCIT_C65755 @default.
- NCIT_C26655 NCIT_A7 NCIT_C43241 @default.
- NCIT_C26655 NCIT_NHC0 "C26655" @default.
- NCIT_C26655 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C26655 NCIT_P107 "Forodesine Hydrochloride" @default.
- NCIT_C26655 NCIT_P108 "Forodesine Hydrochloride" @default.
- NCIT_C26655 NCIT_P207 "C1175653" @default.
- NCIT_C26655 NCIT_P210 "284490-13-7" @default.
- NCIT_C26655 NCIT_P319 "6SN82Y9U73" @default.
- NCIT_C26655 NCIT_P322 "CTRP" @default.
- NCIT_C26655 NCIT_P322 "FDA" @default.
- NCIT_C26655 NCIT_P322 "GDC" @default.
- NCIT_C26655 NCIT_P325 "A substance being studied in the treatment of some types of leukemia and lymphoma. It is a type of purine nucleoside phosphorylase (PNP) inhibitor." @default.
- NCIT_C26655 NCIT_P329 "301648" @default.
- NCIT_C26655 NCIT_P330 "301648" @default.
- NCIT_C26655 NCIT_P350 "C11H14N4O4.HCl" @default.
- NCIT_C26655 NCIT_P366 "Immucillin-H" @default.
- NCIT_C26655 NCIT_P375 "Forodesine Hydrochloride" @default.
- NCIT_C26655 NCIT_P399 "301648" @default.
- NCIT_C26655 normalizedInformationContent "100" @default.
- NCIT_C26655 referenceCount "1" @default.
- NCIT_C26655 hasExactSynonym "BCX-1777" @default.
- NCIT_C26655 hasExactSynonym "FORODESINE HYDROCHLORIDE" @default.
- NCIT_C26655 hasExactSynonym "Fodosine" @default.
- NCIT_C26655 hasExactSynonym "Forodesine Hydrochloride" @default.
- NCIT_C26655 hasExactSynonym "Immucillin-H" @default.
- NCIT_C26655 hasExactSynonym "Mundesine" @default.
- NCIT_C26655 hasExactSynonym "forodesine hydrochloride" @default.
- NCIT_C26655 inSubset NCIT_C116977 @default.
- NCIT_C26655 inSubset NCIT_C116978 @default.
- NCIT_C26655 inSubset NCIT_C128784 @default.
- NCIT_C26655 inSubset NCIT_C157711 @default.
- NCIT_C26655 inSubset NCIT_C157712 @default.
- NCIT_C26655 inSubset NCIT_C176424 @default.
- NCIT_C26655 inSubset NCIT_C177537 @default.
- NCIT_C26655 inSubset NCIT_C63923 @default.
- NCIT_C26655 type Class @default.
- NCIT_C26655 isDefinedBy ncit.owl @default.
- NCIT_C26655 label "Forodesine Hydrochloride" @default.
- NCIT_C26655 subClassOf NCIT_C1908 @default.
- NCIT_C26655 subClassOf NCIT_C1909 @default.
- NCIT_C26655 subClassOf NCIT_C2151 @default.
- NCIT_C26655 subClassOf NCIT_C26655 @default.
- NCIT_C26655 subClassOf NCIT_C471 @default.