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- NCIT_C26666 IAO_0000115 "An orally active synthetic enantiomer of flurbiprofen. Tarenflurbil activates c-Jun N terminal kinase, increases AP-1 binding to DNA, and downregulates cyclin D1 expression, resulting in arrest of tumor cells in the G1 phase of the cell cycle and apoptosis. This agent also affects the expression of nuclear factor kappa B, a rapid response transcription factor that stimulates the immune response to tumor cells. R-flurbiprofen does not inhibit the enzyme cyclo-oxygenase." @default.
- NCIT_C26666 NCIT_A32 NCIT_C1909 @default.
- NCIT_C26666 NCIT_NHC0 "C26666" @default.
- NCIT_C26666 NCIT_P106 "Organic Chemical" @default.
- NCIT_C26666 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C26666 NCIT_P108 "Tarenflurbil" @default.
- NCIT_C26666 NCIT_P175 "685699" @default.
- NCIT_C26666 NCIT_P207 "C1527219" @default.
- NCIT_C26666 NCIT_P210 "51543-40-9" @default.
- NCIT_C26666 NCIT_P319 "501W00OOWA" @default.
- NCIT_C26666 NCIT_P322 "FDA" @default.
- NCIT_C26666 NCIT_P322 "GDC" @default.
- NCIT_C26666 NCIT_P325 "A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs)." @default.
- NCIT_C26666 NCIT_P329 "257154" @default.
- NCIT_C26666 NCIT_P330 "257154" @default.
- NCIT_C26666 NCIT_P350 "C15H13FO2" @default.
- NCIT_C26666 NCIT_P366 "R-flurbiprofen" @default.
- NCIT_C26666 NCIT_P368 "CHEBI:38666" @default.
- NCIT_C26666 NCIT_P375 "Tarenflurbil" @default.
- NCIT_C26666 NCIT_P399 "257154" @default.
- NCIT_C26666 normalizedInformationContent "100" @default.
- NCIT_C26666 referenceCount "1" @default.
- NCIT_C26666 hasExactSynonym "(R)-2-Fluoro-alpha-methyl[1,1'-biphenyl]-4-acetic Acid" @default.
- NCIT_C26666 hasExactSynonym "E-7869" @default.
- NCIT_C26666 hasExactSynonym "Flurizan" @default.
- NCIT_C26666 hasExactSynonym "MPC-7869" @default.
- NCIT_C26666 hasExactSynonym "R-Flurbiprofen" @default.
- NCIT_C26666 hasExactSynonym "R-flurbiprofen" @default.
- NCIT_C26666 hasExactSynonym "TARENFLURBIL" @default.
- NCIT_C26666 hasExactSynonym "Tarenflurbil" @default.
- NCIT_C26666 inSubset NCIT_C128784 @default.
- NCIT_C26666 inSubset NCIT_C157711 @default.
- NCIT_C26666 inSubset NCIT_C157712 @default.
- NCIT_C26666 inSubset NCIT_C176424 @default.
- NCIT_C26666 inSubset NCIT_C177537 @default.
- NCIT_C26666 inSubset NCIT_C63923 @default.
- NCIT_C26666 type Class @default.
- NCIT_C26666 isDefinedBy ncit.owl @default.
- NCIT_C26666 label "Tarenflurbil" @default.
- NCIT_C26666 subClassOf NCIT_C1908 @default.
- NCIT_C26666 subClassOf NCIT_C1909 @default.
- NCIT_C26666 subClassOf NCIT_C2189 @default.
- NCIT_C26666 subClassOf NCIT_C2198 @default.
- NCIT_C26666 subClassOf NCIT_C2356 @default.
- NCIT_C26666 subClassOf NCIT_C241 @default.
- NCIT_C26666 subClassOf NCIT_C257 @default.
- NCIT_C26666 subClassOf NCIT_C26666 @default.
- NCIT_C26666 subClassOf NCIT_C274 @default.
- NCIT_C26666 subClassOf NCIT_C78272 @default.