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- NCIT_C26669 IAO_0000115 "A vitamin D3 analogue with potential antineoplastic activity. Seocalcitol binds to and activates the vitamin D receptor, a cytoplasmic polypeptide expressed in normal vitamin D responsive tissues, but also overexpressed in certain cancers including hepatocellular carcinoma and pancreatic cancer. Mediated through vitamin D receptor, this agent induces cancer cell differentiation, inhibits cancer cell growth and induces apoptosis. In addition, seocalcitol may also induce growth arrest and apoptosis independent of vitamin D receptor activation through mechanisms that are not fully elucidated." @default.
- NCIT_C26669 NCIT_A32 NCIT_C1909 @default.
- NCIT_C26669 NCIT_NHC0 "C26669" @default.
- NCIT_C26669 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C26669 NCIT_P108 "Seocalcitol" @default.
- NCIT_C26669 NCIT_P207 "C0905598" @default.
- NCIT_C26669 NCIT_P210 "134404-52-7" @default.
- NCIT_C26669 NCIT_P319 "Q0OZ0D9223" @default.
- NCIT_C26669 NCIT_P322 "FDA" @default.
- NCIT_C26669 NCIT_P322 "GDC" @default.
- NCIT_C26669 NCIT_P325 "A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called vitamin D analogs." @default.
- NCIT_C26669 NCIT_P329 "298863" @default.
- NCIT_C26669 NCIT_P330 "298863" @default.
- NCIT_C26669 NCIT_P350 "C30H46O3" @default.
- NCIT_C26669 NCIT_P366 "Seocalcitol" @default.
- NCIT_C26669 NCIT_P375 "Seocalcitol" @default.
- NCIT_C26669 NCIT_P399 "298863" @default.
- NCIT_C26669 normalizedInformationContent "100" @default.
- NCIT_C26669 referenceCount "1" @default.
- NCIT_C26669 hasExactSynonym "(1R-(1alpha(1R*,2E,4E),3abeta,4E(1R*,3S*,5Z),7aalpha))-5-((1-(6-Ethyl-6-hydroxy-1-methyl-2,4-octadienyl)octahydro-7a-methyl-4H-inden-4-ylidene)ethylidene)-4-methylene-1,3-cyclohexanediol" @default.
- NCIT_C26669 hasExactSynonym "1(S),3(R)-Dihydroxy-20(R)-(5'-ethyl-5'-hydroxyhepta-1'(E),3'(E)-dien-1'-yl)-9,10-secopregna-5(Z),7(E),10(19)-triene" @default.
- NCIT_C26669 hasExactSynonym "EB1089" @default.
- NCIT_C26669 hasExactSynonym "SEOCALCITOL" @default.
- NCIT_C26669 hasExactSynonym "Seocalcitol" @default.
- NCIT_C26669 hasExactSynonym "seocalcitol" @default.
- NCIT_C26669 inSubset NCIT_C128784 @default.
- NCIT_C26669 inSubset NCIT_C157711 @default.
- NCIT_C26669 inSubset NCIT_C157712 @default.
- NCIT_C26669 inSubset NCIT_C176424 @default.
- NCIT_C26669 inSubset NCIT_C177537 @default.
- NCIT_C26669 inSubset NCIT_C63923 @default.
- NCIT_C26669 type Class @default.
- NCIT_C26669 isDefinedBy ncit.owl @default.
- NCIT_C26669 label "Seocalcitol" @default.
- NCIT_C26669 subClassOf NCIT_C1505 @default.
- NCIT_C26669 subClassOf NCIT_C1908 @default.
- NCIT_C26669 subClassOf NCIT_C26669 @default.
- NCIT_C26669 subClassOf NCIT_C39713 @default.