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- NCIT_C2676 IAO_0000115 "A neuroattenuated, replication-competent, recombinant herpes simplex virus-1 (HSV-1) with potential oncolytic activity. Upon intracerebral administration, oncolytic HSV-1 G207 preferentially replicates within glioma cells, which may elicit tumor-specific systemic immune and cytotoxic T lymphocyte (CTL) responses in addition to direct cytopathic effects. Derived from wild-type HSV-1 strain F, this agent has been neuroattenuated by deletions in both copies of the gamma34.5 gene, the major determinant of HSV neurovirulence. In addition, the HSV-1 gene UL39, encoding the viral ribonucleotide reductase large subunit infected cell protein 6 (ICP6), has been inactivated through the insertion of the Escherichia coli lacZ gene. By inactivating UL39, viral ribonucleotide reductase activity is disrupted, resulting in the inhibition of nucleotide metabolism and viral DNA synthesis in nondividing cells but not in dividing cells." @default.
- NCIT_C2676 NCIT_A32 NCIT_C1909 @default.
- NCIT_C2676 NCIT_NHC0 "C2676" @default.
- NCIT_C2676 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C2676 NCIT_P106 "Virus" @default.
- NCIT_C2676 NCIT_P108 "Oncolytic HSV-1 G207" @default.
- NCIT_C2676 NCIT_P207 "C1134718" @default.
- NCIT_C2676 NCIT_P322 "GDC" @default.
- NCIT_C2676 NCIT_P329 "38634" @default.
- NCIT_C2676 NCIT_P330 "38634" @default.
- NCIT_C2676 NCIT_P366 "G207" @default.
- NCIT_C2676 NCIT_P375 "Oncolytic HSV-1 G207" @default.
- NCIT_C2676 NCIT_P399 "38634" @default.
- NCIT_C2676 normalizedInformationContent "100" @default.
- NCIT_C2676 referenceCount "1" @default.
- NCIT_C2676 hasExactSynonym "G207" @default.
- NCIT_C2676 hasExactSynonym "Oncolytic HSV-1 G207" @default.
- NCIT_C2676 inSubset NCIT_C128784 @default.
- NCIT_C2676 inSubset NCIT_C157711 @default.
- NCIT_C2676 inSubset NCIT_C157712 @default.
- NCIT_C2676 inSubset NCIT_C176424 @default.
- NCIT_C2676 inSubset NCIT_C177537 @default.
- NCIT_C2676 type Class @default.
- NCIT_C2676 isDefinedBy ncit.owl @default.
- NCIT_C2676 label "Oncolytic HSV-1 G207" @default.
- NCIT_C2676 subClassOf NCIT_C129821 @default.
- NCIT_C2676 subClassOf NCIT_C1908 @default.
- NCIT_C2676 subClassOf NCIT_C1909 @default.
- NCIT_C2676 subClassOf NCIT_C2676 @default.
- NCIT_C2676 subClassOf NCIT_C274 @default.
- NCIT_C2676 subClassOf NCIT_C307 @default.
- NCIT_C2676 subClassOf NCIT_C717 @default.