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- NCIT_C2702 IAO_0000115 "A sphingomyelin/cholesterol liposomal formulation of vincristine sulfate with potential antineoplastic activity. Vincristine, a vinca alkaloid isolated from the plant Vinca rosea, irreversibly binds to and stabilizes tubulin, thereby interrupting microtubule assembly/disassembly dynamics, thereby preventing the formation of the mitotic spindle and leading to cell cycle arrest in metaphase. Liposomal encapsulation prolongs bioavailability of vincristine, increases its delivery to tumor tissues and reduces its toxicity profile. Compared to standard liposomal delivery, sphingosomal drug delivery further increases circulation time of serum drug and enhances drug accumulation at tumor sites, thereby leading to a further increase in efficacy." @default.
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- NCIT_C2702 NCIT_NHC0 "C2702" @default.
- NCIT_C2702 NCIT_P106 "Organic Chemical" @default.
- NCIT_C2702 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C2702 NCIT_P107 "Vincristine Sulfate Liposome" @default.
- NCIT_C2702 NCIT_P108 "Vincristine Sulfate Liposome" @default.
- NCIT_C2702 NCIT_P207 "C0935690" @default.
- NCIT_C2702 NCIT_P302 "acute lymphoblastic leukemia (ALL)" @default.
- NCIT_C2702 NCIT_P322 "CTRP" @default.
- NCIT_C2702 NCIT_P322 "GDC" @default.
- NCIT_C2702 NCIT_P329 "38100" @default.
- NCIT_C2702 NCIT_P330 "38100" @default.
- NCIT_C2702 NCIT_P366 "Vincristine_Sulfate_Liposomes" @default.
- NCIT_C2702 NCIT_P375 "Vincristine Sulfate Liposome" @default.
- NCIT_C2702 NCIT_P399 "38100" @default.
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- NCIT_C2702 NCIT_R72 NCIT_C32603 @default.
- NCIT_C2702 NCIT_R72 NCIT_C34070 @default.
- NCIT_C2702 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C2702 referenceCount "2" @default.
- NCIT_C2702 hasExactSynonym "Marqibo" @default.
- NCIT_C2702 hasExactSynonym "Vincristine Sulfate Liposome" @default.
- NCIT_C2702 inSubset NCIT_C116977 @default.
- NCIT_C2702 inSubset NCIT_C116978 @default.
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- NCIT_C2702 type Class @default.
- NCIT_C2702 isDefinedBy ncit.owl @default.
- NCIT_C2702 label "Vincristine Sulfate Liposome" @default.
- NCIT_C2702 subClassOf B15d42aaa77c7a8b1f4c168c1f7374de3 @default.
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