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- NCIT_C2721 IAO_0000115 "A synthetic, 20-base antisense oligodeoxynucleotide that hybridizes to c-raf kinase messenger RNA. ISIS 5132 has been shown to specifically suppress Raf-1 expression both in vitro and in vivo. Raf-1 serine/threonine kinase functions as a critical effector of Ras-mediated signal transduction; constitutive activation of this pathway directly contributes to malignant transformation. (NCI04)" @default.
- NCIT_C2721 NCIT_A32 NCIT_C1909 @default.
- NCIT_C2721 NCIT_NHC0 "C2721" @default.
- NCIT_C2721 NCIT_P106 "Nucleic Acid, Nucleoside, or Nucleotide" @default.
- NCIT_C2721 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C2721 NCIT_P108 "c-raf Antisense Oligonucleotide ISIS 5132" @default.
- NCIT_C2721 NCIT_P175 "719336" @default.
- NCIT_C2721 NCIT_P207 "C0389883" @default.
- NCIT_C2721 NCIT_P210 "177075-18-2" @default.
- NCIT_C2721 NCIT_P319 "48IAF3FDP3" @default.
- NCIT_C2721 NCIT_P322 "FDA" @default.
- NCIT_C2721 NCIT_P322 "GDC" @default.
- NCIT_C2721 NCIT_P325 "A substance that is being studied in the treatment of cancer." @default.
- NCIT_C2721 NCIT_P329 "42994" @default.
- NCIT_C2721 NCIT_P330 "42994" @default.
- NCIT_C2721 NCIT_P366 "ISIS_5132" @default.
- NCIT_C2721 NCIT_P375 "c-raf Antisense Oligonucleotide ISIS 5132" @default.
- NCIT_C2721 NCIT_P399 "42994" @default.
- NCIT_C2721 normalizedInformationContent "100" @default.
- NCIT_C2721 referenceCount "1" @default.
- NCIT_C2721 hasExactSynonym "CGP 69846A" @default.
- NCIT_C2721 hasExactSynonym "CGP69846A" @default.
- NCIT_C2721 hasExactSynonym "ISIS 5132" @default.
- NCIT_C2721 hasExactSynonym "ISIS 5132/CGP69846A" @default.
- NCIT_C2721 hasExactSynonym "ISIS-5132" @default.
- NCIT_C2721 hasExactSynonym "RAF-IK Antisense ODN" @default.
- NCIT_C2721 hasExactSynonym "c-RAF Antisense" @default.
- NCIT_C2721 hasExactSynonym "c-raf Antisense Oligonucleotide ISIS 5132" @default.
- NCIT_C2721 inSubset NCIT_C128784 @default.
- NCIT_C2721 inSubset NCIT_C157711 @default.
- NCIT_C2721 inSubset NCIT_C157712 @default.
- NCIT_C2721 inSubset NCIT_C176424 @default.
- NCIT_C2721 inSubset NCIT_C177537 @default.
- NCIT_C2721 inSubset NCIT_C63923 @default.
- NCIT_C2721 type Class @default.
- NCIT_C2721 isDefinedBy ncit.owl @default.
- NCIT_C2721 label "c-raf Antisense Oligonucleotide ISIS 5132" @default.
- NCIT_C2721 subClassOf NCIT_C1291 @default.
- NCIT_C2721 subClassOf NCIT_C1908 @default.
- NCIT_C2721 subClassOf NCIT_C1909 @default.
- NCIT_C2721 subClassOf NCIT_C1962 @default.
- NCIT_C2721 subClassOf NCIT_C2721 @default.
- NCIT_C2721 subClassOf NCIT_C307 @default.