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- NCIT_C2722 IAO_0000115 "A synthetic triarylimidazole with potential antineoplastic activity. As a Raf kinase inhibitor, L-779450 competes with ATP for binding to the Raf-1 and A-Raf catalytic sites, thus inhibiting their enzymatic activities and blocking various signal transduction pathways that depend on Raf-1 kinase (particularly the Ras-Raf-MEK-ERK cascade which is often up-regulated in neoplasms). (NCI04)" @default.
- NCIT_C2722 NCIT_A32 NCIT_C1909 @default.
- NCIT_C2722 NCIT_NHC0 "C2722" @default.
- NCIT_C2722 NCIT_P106 "Organic Chemical" @default.
- NCIT_C2722 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C2722 NCIT_P108 "RAF Kinase Inhibitor L-779450" @default.
- NCIT_C2722 NCIT_P207 "C1517681" @default.
- NCIT_C2722 NCIT_P322 "GDC" @default.
- NCIT_C2722 NCIT_P366 "L-779450" @default.
- NCIT_C2722 NCIT_P375 "RAF Kinase Inhibitor L-779450" @default.
- NCIT_C2722 normalizedInformationContent "100" @default.
- NCIT_C2722 referenceCount "1" @default.
- NCIT_C2722 hasExactSynonym "L-779,450" @default.
- NCIT_C2722 hasExactSynonym "L-779450" @default.
- NCIT_C2722 hasExactSynonym "RAF Kinase Inhibitor L-779450" @default.
- NCIT_C2722 inSubset NCIT_C128784 @default.
- NCIT_C2722 inSubset NCIT_C157711 @default.
- NCIT_C2722 inSubset NCIT_C157712 @default.
- NCIT_C2722 inSubset NCIT_C177537 @default.
- NCIT_C2722 type Class @default.
- NCIT_C2722 isDefinedBy ncit.owl @default.
- NCIT_C2722 label "RAF Kinase Inhibitor L-779450" @default.
- NCIT_C2722 subClassOf NCIT_C129824 @default.
- NCIT_C2722 subClassOf NCIT_C129825 @default.
- NCIT_C2722 subClassOf NCIT_C1404 @default.
- NCIT_C2722 subClassOf NCIT_C163758 @default.
- NCIT_C2722 subClassOf NCIT_C1908 @default.
- NCIT_C2722 subClassOf NCIT_C1909 @default.
- NCIT_C2722 subClassOf NCIT_C2189 @default.
- NCIT_C2722 subClassOf NCIT_C2336 @default.
- NCIT_C2722 subClassOf NCIT_C2722 @default.
- NCIT_C2722 subClassOf NCIT_C274 @default.
- NCIT_C2722 subClassOf NCIT_C471 @default.
- NCIT_C2722 subClassOf NCIT_C61074 @default.