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- NCIT_C2736 IAO_0000115 "A water-soluble phosphate prodrug of N-acetylcolchinol with potential antiangiogenesis and antineoplastic activities. ZD-6126 is converted in vivo into N-acetylcolchinol. N-acetylcolchinol binds to and destabilizes the tubulin cytoskeleton of endothelial cells in tumor blood vessels, which may result in tumor endothelial cell apoptosis, the selective occlusion of tumor blood vessels, cessation of tumor blood flow, and tumor necrosis." @default.
- NCIT_C2736 NCIT_A32 NCIT_C1909 @default.
- NCIT_C2736 NCIT_NHC0 "C2736" @default.
- NCIT_C2736 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C2736 NCIT_P108 "Vascular Disrupting Agent ZD6126" @default.
- NCIT_C2736 NCIT_P171 "18219445" @default.
- NCIT_C2736 NCIT_P207 "C1122628" @default.
- NCIT_C2736 NCIT_P210 "219923-05-4" @default.
- NCIT_C2736 NCIT_P319 "GBO3S6M9W7" @default.
- NCIT_C2736 NCIT_P322 "FDA" @default.
- NCIT_C2736 NCIT_P322 "GDC" @default.
- NCIT_C2736 NCIT_P325 "A substance that has been studied in the treatment of several types of cancer. ZD6126 destroys blood vessels in tumors and may prevent the growth of new blood vessels that tumors need to grow. It is a type of vascular targeting agent and a type of antiangiogenesis agent." @default.
- NCIT_C2736 NCIT_P329 "353153" @default.
- NCIT_C2736 NCIT_P330 "353153" @default.
- NCIT_C2736 NCIT_P350 "C20H24NO8P" @default.
- NCIT_C2736 NCIT_P366 "ZD-6126" @default.
- NCIT_C2736 NCIT_P375 "Vascular Disrupting Agent ZD6126" @default.
- NCIT_C2736 NCIT_P399 "353153" @default.
- NCIT_C2736 NCIT_R124 NCIT_C17828 @default.
- NCIT_C2736 NCIT_R124 NCIT_C20480 @default.
- NCIT_C2736 NCIT_R124 NCIT_C40795 @default.
- NCIT_C2736 NCIT_R124 NCIT_C40798 @default.
- NCIT_C2736 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C2736 referenceCount "2" @default.
- NCIT_C2736 hasExactSynonym "ANG453" @default.
- NCIT_C2736 hasExactSynonym "N-[(5S)-6,7-Dihydro-9,10,11-trimethoxy-3-(phosphonooxy)-5H-dibenzo[a,c]cyclohepten-5-yl]acetamide" @default.
- NCIT_C2736 hasExactSynonym "N-acetylcochinol-O-phosphate" @default.
- NCIT_C2736 hasExactSynonym "Vascular Disrupting Agent ZD6126" @default.
- NCIT_C2736 hasExactSynonym "ZD-6126" @default.
- NCIT_C2736 hasExactSynonym "ZD6126" @default.
- NCIT_C2736 hasExactSynonym "ZM-445526" @default.
- NCIT_C2736 inSubset NCIT_C128784 @default.
- NCIT_C2736 inSubset NCIT_C157711 @default.
- NCIT_C2736 inSubset NCIT_C157712 @default.
- NCIT_C2736 inSubset NCIT_C176424 @default.
- NCIT_C2736 inSubset NCIT_C177537 @default.
- NCIT_C2736 inSubset NCIT_C63923 @default.
- NCIT_C2736 type Class @default.
- NCIT_C2736 isDefinedBy ncit.owl @default.
- NCIT_C2736 label "Vascular Disrupting Agent ZD6126" @default.
- NCIT_C2736 subClassOf NCIT_C186664 @default.
- NCIT_C2736 subClassOf NCIT_C1908 @default.
- NCIT_C2736 subClassOf NCIT_C1909 @default.
- NCIT_C2736 subClassOf NCIT_C25974 @default.
- NCIT_C2736 subClassOf NCIT_C273 @default.
- NCIT_C2736 subClassOf NCIT_C2736 @default.
- NCIT_C2736 subClassOf NCIT_C274 @default.