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- NCIT_C28144 IAO_0000115 "Drug tolerance - a reduction in the sensitivity to a drug following its repeated administration, in which increased doses are required to produce the same magnitude of effect previously produced by a smaller dose. This increase in dose may be necessitated by changes in the metabolism of the drug, or a cellular, physiological or behavioral adaptation to the effects of the drug." @default.
- NCIT_C28144 NCIT_NHC0 "C28144" @default.
- NCIT_C28144 NCIT_P106 "Organism Attribute" @default.
- NCIT_C28144 NCIT_P108 "Drug Tolerance" @default.
- NCIT_C28144 NCIT_P200 "Biological_Effect_of_Chemicals" @default.
- NCIT_C28144 NCIT_P203 "Properties_or_Attributes_Kind" @default.
- NCIT_C28144 NCIT_P310 "Retired_Concept" @default.
- NCIT_C28144 NCIT_P325 "A condition that occurs when the body gets used to a medicine so that either more medicine is needed or different medicine is needed." @default.
- NCIT_C28144 NCIT_P325 "Progressive diminution of the susceptibility of a human or animal to the effects of a drug, resulting from its continued administration. It should be differentiated from DRUG RESISTANCE wherein an organism, disease, or tissue fails to respond to the intended effectiveness of a chemical or drug. It should also be differentiated from MAXIMUM TOLERATED DOSE and NO-OBSERVED-ADVERSE-EFFECT LEVEL." @default.
- NCIT_C28144 normalizedInformationContent "100" @default.
- NCIT_C28144 referenceCount "1" @default.
- NCIT_C28144 hasExactSynonym "Drug Tolerance" @default.
- NCIT_C28144 hasExactSynonym "drug tolerance" @default.
- NCIT_C28144 type Class @default.
- NCIT_C28144 isDefinedBy ncit.owl @default.
- NCIT_C28144 label "Drug Tolerance" @default.
- NCIT_C28144 subClassOf NCIT_C28144 @default.
- NCIT_C28144 subClassOf NCIT_C28428 @default.
- NCIT_C28144 subClassOf NCIT_C83480 @default.
- NCIT_C28144 deprecated "true" @default.