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- NCIT_C28235 IAO_0000115 "The hydrochloride salt of the L-valyl ester of the antiviral drug acyclovir. Orally administered, valacyclovir is rapidly converted to acyclovir which inhibits viral DNA replication after further conversion to the nucleotide analog acyclovir triphosphate by viral thymidine kinase, cellular guanyl cyclase, and a number of other cellular enzymes. Acyclovir triphosphate competitively inhibits viral DNA polymerase; incorporates into and terminates the growing viral DNA chain; and inactivates viral DNA polymerase. The greater antiviral activity of acyclovir against herpes simplex virus (HSV) compared with varicella-zoster virus (VZV) is due to its more efficient phosphorylation by HSV thymidine kinase." @default.
- NCIT_C28235 NCIT_A5 NCIT_C29535 @default.
- NCIT_C28235 NCIT_NHC0 "C28235" @default.
- NCIT_C28235 NCIT_P106 "Organic Chemical" @default.
- NCIT_C28235 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C28235 NCIT_P107 "Valacyclovir" @default.
- NCIT_C28235 NCIT_P108 "Valacyclovir" @default.
- NCIT_C28235 NCIT_P207 "C0249458" @default.
- NCIT_C28235 NCIT_P210 "124832-26-4" @default.
- NCIT_C28235 NCIT_P319 "MZ1IW7Q79D" @default.
- NCIT_C28235 NCIT_P322 "CTRP" @default.
- NCIT_C28235 NCIT_P322 "FDA" @default.
- NCIT_C28235 NCIT_P325 "A substance that is being studied in the prevention of fungal, bacterial, and viral infections in patients undergoing donor stem cell transplantation with cells that are infected with cytomegalovirus. It belongs to the family of drugs called antivirals." @default.
- NCIT_C28235 NCIT_P329 "257236" @default.
- NCIT_C28235 NCIT_P330 "257236" @default.
- NCIT_C28235 NCIT_P350 "C13H20N6O4" @default.
- NCIT_C28235 NCIT_P366 "Valacyclovir" @default.
- NCIT_C28235 NCIT_P368 "CHEBI:35854" @default.
- NCIT_C28235 NCIT_P399 "257236" @default.
- NCIT_C28235 normalizedInformationContent "100" @default.
- NCIT_C28235 referenceCount "1" @default.
- NCIT_C28235 hasExactSynonym "L-Valine ester with 9-((2-hydroxyethoxy)methyl)guanine" @default.
- NCIT_C28235 hasExactSynonym "VALACYCLOVIR" @default.
- NCIT_C28235 hasExactSynonym "ValACV" @default.
- NCIT_C28235 hasExactSynonym "Valaciclovir" @default.
- NCIT_C28235 hasExactSynonym "Valacyclovir" @default.
- NCIT_C28235 hasExactSynonym "Zelitrex" @default.
- NCIT_C28235 hasExactSynonym "valacyclovir" @default.
- NCIT_C28235 inSubset NCIT_C116977 @default.
- NCIT_C28235 inSubset NCIT_C116978 @default.
- NCIT_C28235 inSubset NCIT_C176424 @default.
- NCIT_C28235 inSubset NCIT_C63923 @default.
- NCIT_C28235 type Class @default.
- NCIT_C28235 isDefinedBy ncit.owl @default.
- NCIT_C28235 label "Valacyclovir" @default.
- NCIT_C28235 subClassOf NCIT_C1908 @default.
- NCIT_C28235 subClassOf NCIT_C1909 @default.
- NCIT_C28235 subClassOf NCIT_C254 @default.
- NCIT_C28235 subClassOf NCIT_C281 @default.
- NCIT_C28235 subClassOf NCIT_C28235 @default.
- NCIT_C28235 subClassOf NCIT_C29575 @default.
- NCIT_C28235 subClassOf NCIT_C471 @default.