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- NCIT_C2825 IAO_0000115 "The racemic form of a synthetic quinoxaline phenoxypropionic acid derivative with antineoplastic properties. XK469R selectively inhibits topoisomerase II by stabilizing the enzyme-DNA intermediates in which topoisomerase subunits are covalently linked to DNA through 5-phosphotyrosyl linkages, thereby interfering with DNA repair and replication, RNA and protein synthesis. This agent possesses unusual solid tumor selectivity and activity against multidrug-resistant cancer cells. XK469R is more water soluble and active than the pure isomers, R(+)XK469 and S(-)XK469. (NCI05)" @default.
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- NCIT_C2825 NCIT_NHC0 "C2825" @default.
- NCIT_C2825 NCIT_P106 "Organic Chemical" @default.
- NCIT_C2825 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C2825 NCIT_P108 "Topoisomerase-II Inhibitor Racemic XK469" @default.
- NCIT_C2825 NCIT_P175 "698215" @default.
- NCIT_C2825 NCIT_P207 "C1611867" @default.
- NCIT_C2825 NCIT_P210 "157542-91-1" @default.
- NCIT_C2825 NCIT_P322 "GDC" @default.
- NCIT_C2825 NCIT_P329 "440966" @default.
- NCIT_C2825 NCIT_P330 "440966" @default.
- NCIT_C2825 NCIT_P366 "XK469R" @default.
- NCIT_C2825 NCIT_P375 "Topoisomerase-II Inhibitor Racemic XK469" @default.
- NCIT_C2825 NCIT_P399 "440966" @default.
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- NCIT_C2825 NCIT_R146 NCIT_C26548 @default.
- NCIT_C2825 normalizedInformationContent "100" @default.
- NCIT_C2825 referenceCount "1" @default.
- NCIT_C2825 hasExactSynonym "Propanoic acid, 2-[4-[(7-chloro-2-quinoxalinyl)oxy]-phenoxy]-, (+ /-)-" @default.
- NCIT_C2825 hasExactSynonym "Topoisomerase-II Inhibitor Racemic XK469" @default.
- NCIT_C2825 hasExactSynonym "XK469 Racemic" @default.
- NCIT_C2825 hasExactSynonym "XK469R" @default.
- NCIT_C2825 inSubset NCIT_C128784 @default.
- NCIT_C2825 inSubset NCIT_C157711 @default.
- NCIT_C2825 inSubset NCIT_C157712 @default.
- NCIT_C2825 inSubset NCIT_C176424 @default.
- NCIT_C2825 inSubset NCIT_C177537 @default.
- NCIT_C2825 type Class @default.
- NCIT_C2825 isDefinedBy ncit.owl @default.
- NCIT_C2825 label "Topoisomerase-II Inhibitor Racemic XK469" @default.
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