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- NCIT_C2828 IAO_0000115 "The hydrochloride salt of a semisynthetic derivative of camptothecin with antineoplastic activity. During the S phase of the cell cycle, topotecan selectively stabilizes topoisomerase I-DNA covalent complexes, inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when complexes are encountered by the DNA replication machinery. Camptothecin is a cytotoxic quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata." @default.
- NCIT_C2828 NCIT_A32 NCIT_C1909 @default.
- NCIT_C2828 NCIT_A6 NCIT_C1413 @default.
- NCIT_C2828 NCIT_A7 NCIT_C16516 @default.
- NCIT_C2828 NCIT_NHC0 "C2828" @default.
- NCIT_C2828 NCIT_P106 "Organic Chemical" @default.
- NCIT_C2828 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C2828 NCIT_P107 "Topotecan Hydrochloride" @default.
- NCIT_C2828 NCIT_P108 "Topotecan Hydrochloride" @default.
- NCIT_C2828 NCIT_P175 "609699" @default.
- NCIT_C2828 NCIT_P207 "C0886549" @default.
- NCIT_C2828 NCIT_P210 "119413-54-6" @default.
- NCIT_C2828 NCIT_P302 "Small Cell Lung Carcinoma; Cervical Cancer" @default.
- NCIT_C2828 NCIT_P319 "956S425ZCY" @default.
- NCIT_C2828 NCIT_P322 "CTRP" @default.
- NCIT_C2828 NCIT_P322 "FDA" @default.
- NCIT_C2828 NCIT_P322 "GDC" @default.
- NCIT_C2828 NCIT_P325 "A drug used to treat certain types of ovarian cancer, lung cancer, and cervical cancer. Hycamtin is a type of topoisomerase inhibitor." @default.
- NCIT_C2828 NCIT_P329 "41185" @default.
- NCIT_C2828 NCIT_P330 "41185" @default.
- NCIT_C2828 NCIT_P350 "C23H23N3O5.HCl" @default.
- NCIT_C2828 NCIT_P366 "Topotecan_Hydrochloride" @default.
- NCIT_C2828 NCIT_P375 "Topotecan Hydrochloride" @default.
- NCIT_C2828 NCIT_P399 "41185" @default.
- NCIT_C2828 NCIT_R124 NCIT_C17710 @default.
- NCIT_C2828 NCIT_R124 NCIT_C17828 @default.
- NCIT_C2828 NCIT_R124 NCIT_C28498 @default.
- NCIT_C2828 NCIT_R124 NCIT_C40576 @default.
- NCIT_C2828 NCIT_R124 NCIT_C40577 @default.
- NCIT_C2828 NCIT_R125 NCIT_C16507 @default.
- NCIT_C2828 NCIT_R125 NCIT_C16514 @default.
- NCIT_C2828 NCIT_R125 NCIT_C16956 @default.
- NCIT_C2828 NCIT_R125 NCIT_C17710 @default.
- NCIT_C2828 NCIT_R125 NCIT_C17828 @default.
- NCIT_C2828 NCIT_R125 NCIT_C18264 @default.
- NCIT_C2828 NCIT_R125 NCIT_C19154 @default.
- NCIT_C2828 NCIT_R125 NCIT_C21080 @default.
- NCIT_C2828 NCIT_R125 NCIT_C25830 @default.
- NCIT_C2828 NCIT_R125 NCIT_C28498 @default.
- NCIT_C2828 NCIT_R125 NCIT_C40828 @default.
- NCIT_C2828 NCIT_R125 NCIT_C41543 @default.
- NCIT_C2828 NCIT_R146 NCIT_C16516 @default.
- NCIT_C2828 NCIT_R146 NCIT_C16554 @default.
- NCIT_C2828 NCIT_R146 NCIT_C16759 @default.
- NCIT_C2828 NCIT_R146 NCIT_C17021 @default.
- NCIT_C2828 NCIT_R146 NCIT_C20027 @default.
- NCIT_C2828 NCIT_R146 NCIT_C20646 @default.
- NCIT_C2828 NCIT_R146 NCIT_C26548 @default.
- NCIT_C2828 normalizedInformationContent "83.556969816060246" @default.
- NCIT_C2828 referenceCount "12" @default.
- NCIT_C2828 hasExactSynonym "(S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7] indolizino[1,2-b] quinoline-3,14-(4H,12H)-dione Monohydrochloride" @default.
- NCIT_C2828 hasExactSynonym "Evotopin" @default.
- NCIT_C2828 hasExactSynonym "Hycamptamine" @default.
- NCIT_C2828 hasExactSynonym "Hycamtin" @default.
- NCIT_C2828 hasExactSynonym "Potactasol" @default.
- NCIT_C2828 hasExactSynonym "SKF S-104864-A" @default.
- NCIT_C2828 hasExactSynonym "TOPOTECAN HYDROCHLORIDE" @default.
- NCIT_C2828 hasExactSynonym "Topotec" @default.
- NCIT_C2828 hasExactSynonym "Topotecan HCl" @default.
- NCIT_C2828 hasExactSynonym "Topotecan Hydrochloride" @default.
- NCIT_C2828 hasExactSynonym "Topotecan hydrochloride" @default.
- NCIT_C2828 hasExactSynonym "topotecan hydrochloride (oral)" @default.
- NCIT_C2828 hasExactSynonym "topotecan hydrochloride" @default.
- NCIT_C2828 inSubset NCIT_C116977 @default.
- NCIT_C2828 inSubset NCIT_C116978 @default.
- NCIT_C2828 inSubset NCIT_C128784 @default.
- NCIT_C2828 inSubset NCIT_C157711 @default.
- NCIT_C2828 inSubset NCIT_C157712 @default.
- NCIT_C2828 inSubset NCIT_C176424 @default.
- NCIT_C2828 inSubset NCIT_C177537 @default.
- NCIT_C2828 inSubset NCIT_C63923 @default.
- NCIT_C2828 type Class @default.
- NCIT_C2828 isDefinedBy ncit.owl @default.
- NCIT_C2828 label "Topotecan Hydrochloride" @default.
- NCIT_C2828 subClassOf B2d4815110dd78bb4f9f55acdf67abd67 @default.
- NCIT_C2828 subClassOf B49f176a87117feccf01ba7b75117f215 @default.
- NCIT_C2828 subClassOf B5e0b379c3b09c0e6a0fba81f96c4fece @default.
- NCIT_C2828 subClassOf B6be66b77210aa3bac2cf7b69876d5bf2 @default.
- NCIT_C2828 subClassOf B75ea8bba65d9f6daee4b612cfe39ae4e @default.
- NCIT_C2828 subClassOf B792566c398b3e64432b6d9e92a7f235f @default.
- NCIT_C2828 subClassOf B93abeff432d075fad80ac6557ade1fd0 @default.
- NCIT_C2828 subClassOf Bd6af19e3dbc7261848fd9d1c0a789a3d @default.
- NCIT_C2828 subClassOf NCIT_C129824 @default.
- NCIT_C2828 subClassOf NCIT_C129825 @default.
- NCIT_C2828 subClassOf NCIT_C1748 @default.
- NCIT_C2828 subClassOf NCIT_C1904 @default.
- NCIT_C2828 subClassOf NCIT_C1908 @default.
- NCIT_C2828 subClassOf NCIT_C1909 @default.
- NCIT_C2828 subClassOf NCIT_C2189 @default.
- NCIT_C2828 subClassOf NCIT_C274 @default.
- NCIT_C2828 subClassOf NCIT_C2828 @default.
- NCIT_C2828 subClassOf NCIT_C2843 @default.
- NCIT_C2828 subClassOf NCIT_C471 @default.