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- NCIT_C2829 IAO_0000115 "The hydrochloride salt form of fluoxetine, a diphenhydramine derivative and selective serotonin reuptake inhibitor with antidepressant, anti-anxiety, antiobsessional and antibulimic activity and with potential immunomodulating activity. Upon administration, fluoxetine binds to the presynaptic serotonin (5-HT) receptor resulting in negative allosteric modulation of the receptor complex, thereby blocking recycling of serotonin by the presynaptic receptor. Inhibition of serotonin reuptake by fluoxetine enhances serotonergic function through serotonin accumulation in the synaptic space, resulting in long-term desensitization and downregulation of 5-HT receptors, preventing 5-HT-mediated signaling and leading to antidepressant, anti-anxiety, antiobsessional and antibulimic effects. In addition, fluoxetine may inhibit the expression of pro-inflammatory cytokines, including interleukin-6 (IL-6). This may prevent IL-6-mediated inflammation and cytokine storm." @default.
- NCIT_C2829 NCIT_A6 NCIT_C506 @default.
- NCIT_C2829 NCIT_NHC0 "C2829" @default.
- NCIT_C2829 NCIT_P106 "Organic Chemical" @default.
- NCIT_C2829 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C2829 NCIT_P108 "Fluoxetine Hydrochloride" @default.
- NCIT_C2829 NCIT_P175 "714457" @default.
- NCIT_C2829 NCIT_P207 "C0733380" @default.
- NCIT_C2829 NCIT_P210 "59333-67-4" @default.
- NCIT_C2829 NCIT_P319 "I9W7N6B1KJ" @default.
- NCIT_C2829 NCIT_P322 "FDA" @default.
- NCIT_C2829 NCIT_P350 "C17H18F3NO.HCl" @default.
- NCIT_C2829 NCIT_P366 "Fluoxetine_Hydrochloride" @default.
- NCIT_C2829 normalizedInformationContent "100" @default.
- NCIT_C2829 referenceCount "1" @default.
- NCIT_C2829 hasExactSynonym "FLUOXETINE HYDROCHLORIDE" @default.
- NCIT_C2829 hasExactSynonym "Fluoxetine Hydrochloride" @default.
- NCIT_C2829 hasExactSynonym "Prozac" @default.
- NCIT_C2829 inSubset NCIT_C173381 @default.
- NCIT_C2829 inSubset NCIT_C173383 @default.
- NCIT_C2829 inSubset NCIT_C63923 @default.
- NCIT_C2829 type Class @default.
- NCIT_C2829 isDefinedBy ncit.owl @default.
- NCIT_C2829 label "Fluoxetine Hydrochloride" @default.
- NCIT_C2829 subClassOf NCIT_C1908 @default.
- NCIT_C2829 subClassOf NCIT_C1909 @default.
- NCIT_C2829 subClassOf NCIT_C265 @default.
- NCIT_C2829 subClassOf NCIT_C2829 @default.
- NCIT_C2829 subClassOf NCIT_C78272 @default.
- NCIT_C2829 subClassOf NCIT_C94725 @default.