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- NCIT_C2842 IAO_0000115 "DNA binding molecules regulate mechanisms central to cellular function, including DNA replication and gene expression. Many small molecules that mimic or block these processes offer potential therapeutic agents. Understanding how complexation affects both the structural and mechanical properties of DNA is an important step towards understanding the functional mechanisms of binding agents, and may also provide a key to more rational drug design. There are three major classes of binding modes: intercalation, groove binding and covalent crosslinking." @default.
- NCIT_C2842 NCIT_NHC0 "C2842" @default.
- NCIT_C2842 NCIT_P106 "Chemical Viewed Functionally" @default.
- NCIT_C2842 NCIT_P108 "DNA Binding Agent" @default.
- NCIT_C2842 NCIT_P207 "C1511661" @default.
- NCIT_C2842 NCIT_P366 "DNA_Binding_Agent" @default.
- NCIT_C2842 normalizedInformationContent "47.129540419541911" @default.
- NCIT_C2842 referenceCount "2951" @default.
- NCIT_C2842 hasExactSynonym "DNA Binding Agent" @default.
- NCIT_C2842 type Class @default.
- NCIT_C2842 isDefinedBy ncit.owl @default.
- NCIT_C2842 label "DNA Binding Agent" @default.
- NCIT_C2842 subClassOf NCIT_C186664 @default.
- NCIT_C2842 subClassOf NCIT_C1908 @default.
- NCIT_C2842 subClassOf NCIT_C1909 @default.
- NCIT_C2842 subClassOf NCIT_C274 @default.
- NCIT_C2842 subClassOf NCIT_C2842 @default.