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- NCIT_C28511 IAO_0000115 "Expressed in various cell types, Nitric Oxide Synthases (NOS Family) are constitutive or inducible calcium/calmodulin stimulated homodimers stabilized by BH4 that bind FAD and FMN cofactors, generally contain a flavodoxin-like domain, and synthesize reactive free radical nitric oxide messenger from L-arginine. NO can act as a neurotransmitter and has antimicrobial and antitumoral activities in macrophages. IL12 requires NOS to stimulate tyrosine-phosphorylation of STAT4 by TYK2 in NK cytotoxicity. Vascular NO (endothelia) inhibits muscle contraction through a cGMP pathway, inhibits platelet aggregation, and mediates VEGF-induced angiogenesis. Endothelial AKT phosphorylates and enhances NOS activity. Potentially influencing energy balance, NO can trigger cGMP-dependent mitochondrial biogenesis mediated by induction of the master regulator PPARGC1. (NCI)" @default.
- NCIT_C28511 NCIT_NHC0 "C28511" @default.
- NCIT_C28511 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C28511 NCIT_P106 "Enzyme" @default.
- NCIT_C28511 NCIT_P107 "Nitric Oxide Synthetase" @default.
- NCIT_C28511 NCIT_P108 "Nitric Oxide Synthetase" @default.
- NCIT_C28511 NCIT_P207 "C0132555" @default.
- NCIT_C28511 NCIT_P322 "CTRP" @default.
- NCIT_C28511 NCIT_P366 "Nitric_Oxide_Synthetase" @default.
- NCIT_C28511 NCIT_R50 NCIT_C12219 @default.
- NCIT_C28511 NCIT_R50 NCIT_C13303 @default.
- NCIT_C28511 NCIT_R50 NCIT_C13379 @default.
- NCIT_C28511 NCIT_R50 NCIT_C13671 @default.
- NCIT_C28511 NCIT_R50 NCIT_C14073 @default.
- NCIT_C28511 NCIT_R50 NCIT_C14134 @default.
- NCIT_C28511 NCIT_R50 NCIT_C21599 @default.
- NCIT_C28511 NCIT_R53 NCIT_C16395 @default.
- NCIT_C28511 NCIT_R53 NCIT_C16945 @default.
- NCIT_C28511 NCIT_R53 NCIT_C17710 @default.
- NCIT_C28511 NCIT_R53 NCIT_C17828 @default.
- NCIT_C28511 NCIT_R53 NCIT_C19899 @default.
- NCIT_C28511 NCIT_R53 NCIT_C21124 @default.
- NCIT_C28511 NCIT_R54 NCIT_C16612 @default.
- NCIT_C28511 NCIT_R54 NCIT_C21281 @default.
- NCIT_C28511 NCIT_R54 NCIT_C25939 @default.
- NCIT_C28511 normalizedInformationContent "89.350088392419622" @default.
- NCIT_C28511 referenceCount "5" @default.
- NCIT_C28511 hasExactSynonym "EC 1.14.13.39" @default.
- NCIT_C28511 hasExactSynonym "NADPH-Diaphorase" @default.
- NCIT_C28511 hasExactSynonym "NO Synthase" @default.
- NCIT_C28511 hasExactSynonym "NOS Family" @default.
- NCIT_C28511 hasExactSynonym "Nitric Oxide Synthase Family" @default.
- NCIT_C28511 hasExactSynonym "Nitric Oxide Synthase" @default.
- NCIT_C28511 hasExactSynonym "Nitric Oxide Synthetase" @default.
- NCIT_C28511 hasExactSynonym "Nitric-Oxide Synthase" @default.
- NCIT_C28511 inSubset NCIT_C116977 @default.
- NCIT_C28511 inSubset NCIT_C142799 @default.
- NCIT_C28511 inSubset NCIT_C142800 @default.
- NCIT_C28511 type Class @default.
- NCIT_C28511 isDefinedBy ncit.owl @default.
- NCIT_C28511 label "Nitric Oxide Synthetase" @default.
- NCIT_C28511 subClassOf Bb360acb581e4ee2c259f0917cf1c90bb @default.
- NCIT_C28511 subClassOf Bff3b6ef95273f0dda9bd1e5246ebe40c @default.
- NCIT_C28511 subClassOf NCIT_C16554 @default.
- NCIT_C28511 subClassOf NCIT_C16946 @default.
- NCIT_C28511 subClassOf NCIT_C17021 @default.
- NCIT_C28511 subClassOf NCIT_C20027 @default.
- NCIT_C28511 subClassOf NCIT_C26548 @default.
- NCIT_C28511 subClassOf NCIT_C28511 @default.