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- NCIT_C286 IAO_0000115 "An enzyme isolated from the bacterium Escherichia coli or the bacterium Erwinia carotovora with antileukemic activity. Asparaginase hydrolyzes L-asparagine to L-aspartic acid and ammonia in leukemic cells, resulting in the depletion of asparagine, inhibition of protein synthesis, cell cycle arrest in the G1 phase, and apoptosis in susceptible leukemic cell populations. Asparagine is critical to protein synthesis in leukemic cells; some leukemic cells cannot synthesize this amino acid de novo due to the absent or deficient expression of the enzyme asparagine synthase. The E. carotovora-derived form of asparaginase is typically reserved for cases of asparaginase hypersensitivity." @default.
- NCIT_C286 NCIT_A32 NCIT_C1909 @default.
- NCIT_C286 NCIT_A7 NCIT_C29607 @default.
- NCIT_C286 NCIT_NHC0 "C286" @default.
- NCIT_C286 NCIT_P106 "Enzyme" @default.
- NCIT_C286 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C286 NCIT_P107 "Asparaginase" @default.
- NCIT_C286 NCIT_P108 "Asparaginase" @default.
- NCIT_C286 NCIT_P175 "109229" @default.
- NCIT_C286 NCIT_P207 "C0003993" @default.
- NCIT_C286 NCIT_P210 "9015-68-3" @default.
- NCIT_C286 NCIT_P302 "Acute lymphocytic leukemia; Acute non-lymphocytic leukemia" @default.
- NCIT_C286 NCIT_P319 "G4FQ3CKY5R" @default.
- NCIT_C286 NCIT_P322 "CTRP" @default.
- NCIT_C286 NCIT_P322 "FDA" @default.
- NCIT_C286 NCIT_P322 "GDC" @default.
- NCIT_C286 NCIT_P325 "A drug that is used to treat acute lymphoblastic leukemia (ALL) and is being studied in the treatment of some other types of cancer. It is an enzyme taken from the bacterium Escherichia coli (E. coli). It breaks down the amino acid asparagine and may block the growth of tumor cells that need asparagine to grow." @default.
- NCIT_C286 NCIT_P329 "41146" @default.
- NCIT_C286 NCIT_P330 "41146" @default.
- NCIT_C286 NCIT_P366 "Asparaginase" @default.
- NCIT_C286 NCIT_P375 "Asparaginase" @default.
- NCIT_C286 NCIT_P399 "41146" @default.
- NCIT_C286 normalizedInformationContent "67.068145939794377" @default.
- NCIT_C286 referenceCount "145" @default.
- NCIT_C286 hasExactSynonym "ASP-1" @default.
- NCIT_C286 hasExactSynonym "ASPARAGINASE" @default.
- NCIT_C286 hasExactSynonym "Asparaginase II" @default.
- NCIT_C286 hasExactSynonym "Asparaginase" @default.
- NCIT_C286 hasExactSynonym "Asparaginase-E.Coli" @default.
- NCIT_C286 hasExactSynonym "Colaspase" @default.
- NCIT_C286 hasExactSynonym "Elspar" @default.
- NCIT_C286 hasExactSynonym "Kidrolase" @default.
- NCIT_C286 hasExactSynonym "L-ASP" @default.
- NCIT_C286 hasExactSynonym "L-Asnase" @default.
- NCIT_C286 hasExactSynonym "L-Asparaginase" @default.
- NCIT_C286 hasExactSynonym "L-Asparagine Amidohydrolase" @default.
- NCIT_C286 hasExactSynonym "L-Asparagine amidohydrolase" @default.
- NCIT_C286 hasExactSynonym "L-asparaginase" @default.
- NCIT_C286 hasExactSynonym "Laspar" @default.
- NCIT_C286 hasExactSynonym "Lcf-ASP" @default.
- NCIT_C286 hasExactSynonym "Leucogen" @default.
- NCIT_C286 hasExactSynonym "Leunase" @default.
- NCIT_C286 hasExactSynonym "MK-965" @default.
- NCIT_C286 hasExactSynonym "Paronal" @default.
- NCIT_C286 hasExactSynonym "Re-82-TAD-15" @default.
- NCIT_C286 hasExactSynonym "Serasa" @default.
- NCIT_C286 hasExactSynonym "Spectrila" @default.
- NCIT_C286 hasExactSynonym "asparaginase" @default.
- NCIT_C286 inSubset NCIT_C116977 @default.
- NCIT_C286 inSubset NCIT_C116978 @default.
- NCIT_C286 inSubset NCIT_C128784 @default.
- NCIT_C286 inSubset NCIT_C142799 @default.
- NCIT_C286 inSubset NCIT_C157711 @default.
- NCIT_C286 inSubset NCIT_C157712 @default.
- NCIT_C286 inSubset NCIT_C176424 @default.
- NCIT_C286 inSubset NCIT_C177537 @default.
- NCIT_C286 inSubset NCIT_C63923 @default.
- NCIT_C286 type Class @default.
- NCIT_C286 isDefinedBy ncit.owl @default.
- NCIT_C286 label "Asparaginase" @default.
- NCIT_C286 subClassOf NCIT_C177280 @default.
- NCIT_C286 subClassOf NCIT_C177430 @default.
- NCIT_C286 subClassOf NCIT_C1908 @default.
- NCIT_C286 subClassOf NCIT_C1909 @default.
- NCIT_C286 subClassOf NCIT_C274 @default.
- NCIT_C286 subClassOf NCIT_C286 @default.
- NCIT_C286 subClassOf NCIT_C29726 @default.
- NCIT_C286 subClassOf NCIT_C307 @default.