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- NCIT_C28672 IAO_0000115 "The G1/S transition in eukaryotic cells is strictly regulated so that DNA replication occurs only once during S phase. The CDC7L1 kinase complex may trigger S phase by directly activating the replication initiation complexes assembled at the origins. Phosphorylation of MCM2 and MCM3 in the MCM complex by the CDC7L1 kinase complex converts the inactive MCM complex into an active helicase. Activator of S Phase Kinase, encoded by the ASK gene, is a cyclin-like regulatory subunit of the CDC7L1 kinase complex. This protein is the major activator of CDC7L1. ASK plays a pivotal role in the G1/S transition in mammalian cells and its function is essential for entry into S phase. ASK interacts with CDC7L1 and stimulates the kinase activity of CDC7L1. CDC7L1-dependent kinase activity reflects the ASK protein level, significantly increasing in cells in S phase, and ASK protein is extensively phosphorylated during S phase, presumably by CDC7L1." @default.
- NCIT_C28672 NCIT_NHC0 "C28672" @default.
- NCIT_C28672 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C28672 NCIT_P106 "Enzyme" @default.
- NCIT_C28672 NCIT_P108 "CDC7L1 Kinase Complex" @default.
- NCIT_C28672 NCIT_P207 "C1332726" @default.
- NCIT_C28672 NCIT_P366 "CDC7L1_Kinase_Complex" @default.
- NCIT_C28672 NCIT_R53 NCIT_C16397 @default.
- NCIT_C28672 NCIT_R53 NCIT_C16750 @default.
- NCIT_C28672 NCIT_R53 NCIT_C17828 @default.
- NCIT_C28672 NCIT_R53 NCIT_C20480 @default.
- NCIT_C28672 NCIT_R53 NCIT_C21102 @default.
- NCIT_C28672 NCIT_R53 NCIT_C25868 @default.
- NCIT_C28672 normalizedInformationContent "92.730304365937428" @default.
- NCIT_C28672 referenceCount "3" @default.
- NCIT_C28672 hasExactSynonym "CDC7L1 Kinase Complex" @default.
- NCIT_C28672 type Class @default.
- NCIT_C28672 isDefinedBy ncit.owl @default.
- NCIT_C28672 label "CDC7L1 Kinase Complex" @default.
- NCIT_C28672 subClassOf B1544551ff96e38950eb59e9bf63dff72 @default.
- NCIT_C28672 subClassOf B48b0638d4075aeafba1f7d192cd9dfd5 @default.
- NCIT_C28672 subClassOf NCIT_C21176 @default.
- NCIT_C28672 subClassOf NCIT_C26548 @default.
- NCIT_C28672 subClassOf NCIT_C28672 @default.