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- NCIT_C28694 IAO_0000115 "A poorly soluble, ortho-naphthoquinone with potential antineoplastic and radiosensitizing activity. Beta-lapachone (b-lap) is bioactivated by NAD(P)H:quinone oxidoreductase-1 (NQO1), creating a futile oxidoreduction that generates high levels of superoxide. In turn, the highly reactive oxygen species (ROS) interact with DNA, thereby causing single-strand DNA breaks and calcium release from endoplasmic reticulum (ER) stores. Eventually, the extensive DNA damage causes hyperactivation of poly(ADP-ribose) polymerase-1 (PARP-1), an enzyme facilitating DNA repair, accompanied by rapid depletion of NAD+/ATP nucleotide levels. As a result, a caspase-independent and ER-stress induced mu-calpain-mediated cell death occurs in NQO1-overexpressing tumor cells. NQO1, a flavoprotein and two-electron oxidoreductase, is overexpressed in a variety of tumors." @default.
- NCIT_C28694 NCIT_A32 NCIT_C1909 @default.
- NCIT_C28694 NCIT_NHC0 "C28694" @default.
- NCIT_C28694 NCIT_P106 "Organic Chemical" @default.
- NCIT_C28694 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C28694 NCIT_P108 "Lapachone" @default.
- NCIT_C28694 NCIT_P175 "26326" @default.
- NCIT_C28694 NCIT_P175 "629749" @default.
- NCIT_C28694 NCIT_P207 "C0053471" @default.
- NCIT_C28694 NCIT_P210 "4707-32-8" @default.
- NCIT_C28694 NCIT_P319 "6N4FA2QQ6A" @default.
- NCIT_C28694 NCIT_P322 "FDA" @default.
- NCIT_C28694 NCIT_P322 "GDC" @default.
- NCIT_C28694 NCIT_P329 "357565" @default.
- NCIT_C28694 NCIT_P330 "357565" @default.
- NCIT_C28694 NCIT_P350 "C15H14O3" @default.
- NCIT_C28694 NCIT_P366 "beta-Lapachone" @default.
- NCIT_C28694 NCIT_P375 "Lapachone" @default.
- NCIT_C28694 NCIT_P399 "357565" @default.
- NCIT_C28694 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C28694 referenceCount "2" @default.
- NCIT_C28694 hasExactSynonym "3,4-Dihydro-2,2-dimethyl-2H-naphtho(1,2-b)pyran-5,6-dione" @default.
- NCIT_C28694 hasExactSynonym "ARQ 501" @default.
- NCIT_C28694 hasExactSynonym "ARQ501" @default.
- NCIT_C28694 hasExactSynonym "Beta-Lap-WJ" @default.
- NCIT_C28694 hasExactSynonym "Beta-Lapachone" @default.
- NCIT_C28694 hasExactSynonym "LAPACHONE" @default.
- NCIT_C28694 hasExactSynonym "Lapachone" @default.
- NCIT_C28694 hasExactSynonym "beta-Lapachone" @default.
- NCIT_C28694 inSubset NCIT_C128784 @default.
- NCIT_C28694 inSubset NCIT_C157711 @default.
- NCIT_C28694 inSubset NCIT_C157712 @default.
- NCIT_C28694 inSubset NCIT_C176424 @default.
- NCIT_C28694 inSubset NCIT_C177537 @default.
- NCIT_C28694 inSubset NCIT_C63923 @default.
- NCIT_C28694 type Class @default.
- NCIT_C28694 isDefinedBy ncit.owl @default.
- NCIT_C28694 label "Lapachone" @default.
- NCIT_C28694 subClassOf NCIT_C129839 @default.
- NCIT_C28694 subClassOf NCIT_C1908 @default.
- NCIT_C28694 subClassOf NCIT_C1909 @default.
- NCIT_C28694 subClassOf NCIT_C2189 @default.
- NCIT_C28694 subClassOf NCIT_C274 @default.
- NCIT_C28694 subClassOf NCIT_C28694 @default.
- NCIT_C28694 subClassOf NCIT_C798 @default.