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- NCIT_C28819 IAO_0000115 "The hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptive activities. Amitriptyline inhibits the re-uptake of norepinephrine and serotonin by the presynaptic neuronal membrane in the central nervous system (CNS), thereby increasing the synaptic concentration of norepinephrine and serotonin. Due to constant stimulation to these receptors, amitriptyline may produce a downregulation of adrenergic and serotonin receptors, which may contribute to the antidepressant activity. In the CNS the antinociceptive activity of this agent may involve high affinity binding to and inhibition of N-methyl-D-aspartate (NMDA) receptors and/or the enhancement of the action of serotonin at the spinal terminals of an opioid-mediated intrinsic analgesia system." @default.
- NCIT_C28819 NCIT_A6 NCIT_C62005 @default.
- NCIT_C28819 NCIT_NHC0 "C28819" @default.
- NCIT_C28819 NCIT_P106 "Organic Chemical" @default.
- NCIT_C28819 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C28819 NCIT_P108 "Amitriptyline Hydrochloride" @default.
- NCIT_C28819 NCIT_P175 "104210" @default.
- NCIT_C28819 NCIT_P175 "169910" @default.
- NCIT_C28819 NCIT_P207 "C0733667" @default.
- NCIT_C28819 NCIT_P210 "549-18-8" @default.
- NCIT_C28819 NCIT_P319 "26LUD4JO9K" @default.
- NCIT_C28819 NCIT_P322 "FDA" @default.
- NCIT_C28819 NCIT_P325 "A drug that is used to treat depression and may be given to treat anxiety, sleep disorders, and pain. It is also being studied in an oral or gel form in the treatment of nerve pain caused by chemotherapy. Amitriptyline hydrochloride is a type of tricyclic antidepressant." @default.
- NCIT_C28819 NCIT_P329 "614649" @default.
- NCIT_C28819 NCIT_P330 "614649" @default.
- NCIT_C28819 NCIT_P350 "C20H23N.ClH" @default.
- NCIT_C28819 NCIT_P366 "Amitriptyline" @default.
- NCIT_C28819 NCIT_P399 "614649" @default.
- NCIT_C28819 NCIT_R122 NCIT_C16484 @default.
- NCIT_C28819 NCIT_R122 NCIT_C16486 @default.
- NCIT_C28819 NCIT_R122 NCIT_C16554 @default.
- NCIT_C28819 NCIT_R122 NCIT_C16865 @default.
- NCIT_C28819 NCIT_R122 NCIT_C16946 @default.
- NCIT_C28819 NCIT_R122 NCIT_C17021 @default.
- NCIT_C28819 NCIT_R122 NCIT_C17287 @default.
- NCIT_C28819 NCIT_R122 NCIT_C17673 @default.
- NCIT_C28819 NCIT_R122 NCIT_C20027 @default.
- NCIT_C28819 NCIT_R122 NCIT_C25948 @default.
- NCIT_C28819 NCIT_R122 NCIT_C26548 @default.
- NCIT_C28819 NCIT_R122 NCIT_C28459 @default.
- NCIT_C28819 NCIT_R122 NCIT_C28750 @default.
- NCIT_C28819 normalizedInformationContent "100" @default.
- NCIT_C28819 referenceCount "1" @default.
- NCIT_C28819 hasExactSynonym "AMITRIPTYLINE HYDROCHLORIDE" @default.
- NCIT_C28819 hasExactSynonym "Amitriptyline Hydrochloride" @default.
- NCIT_C28819 hasExactSynonym "Elavil" @default.
- NCIT_C28819 hasExactSynonym "Endep" @default.
- NCIT_C28819 hasExactSynonym "amitriptyline hydrochloride" @default.
- NCIT_C28819 inSubset NCIT_C176424 @default.
- NCIT_C28819 inSubset NCIT_C63923 @default.
- NCIT_C28819 type Class @default.
- NCIT_C28819 isDefinedBy ncit.owl @default.
- NCIT_C28819 label "Amitriptyline Hydrochloride" @default.
- NCIT_C28819 subClassOf B0e4eea0b005e778084b333fc532c9fb7 @default.
- NCIT_C28819 subClassOf B8136b440bc66b1ae5d2ac45d9b6fde2a @default.
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- NCIT_C28819 subClassOf Bdb987095aae7d69e96fbc31df5929c42 @default.
- NCIT_C28819 subClassOf Be86b21402f0e36e948d1a485074813a7 @default.
- NCIT_C28819 subClassOf Be86efabe7937e6fa5d6cd869ab32e659 @default.
- NCIT_C28819 subClassOf Bf6aeb87d2b03665039fa7535c84f7810 @default.
- NCIT_C28819 subClassOf NCIT_C1908 @default.
- NCIT_C28819 subClassOf NCIT_C1909 @default.
- NCIT_C28819 subClassOf NCIT_C265 @default.
- NCIT_C28819 subClassOf NCIT_C28819 @default.
- NCIT_C28819 subClassOf NCIT_C78272 @default.
- NCIT_C28819 subClassOf NCIT_C94727 @default.