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- NCIT_C28823 IAO_0000115 "A combination formulation of the sodium salts of the antibiotic ampicillin and the beta-lactamase inhibitor sulbactam with antibacterial activity. Ampicillin, a broad-spectrum, semisynthetic penicillin, binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall, thereby interfering with the cross-linking of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. As a result, the cell wall is weakened and the cell lyses. The sulbactam component irreversibly binds to bacterial beta-lactamase at or near its active site, thereby interfering with substrate binding and inhibiting bacterial metabolism of penicillin and cephalosporin beta-lactam antibiotics, effectively extending their antibiotic spectrum to include many beta-lactam-resistant bacteria." @default.
- NCIT_C28823 NCIT_NHC0 "C28823" @default.
- NCIT_C28823 NCIT_P106 "Antibiotic" @default.
- NCIT_C28823 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C28823 NCIT_P108 "Sultamicillin" @default.
- NCIT_C28823 NCIT_P207 "C0147814" @default.
- NCIT_C28823 NCIT_P210 "76497-13-7" @default.
- NCIT_C28823 NCIT_P319 "65DT0ML581" @default.
- NCIT_C28823 NCIT_P322 "FDA" @default.
- NCIT_C28823 NCIT_P329 "500377" @default.
- NCIT_C28823 NCIT_P330 "500377" @default.
- NCIT_C28823 NCIT_P366 "Ampicillin_Sodium-Sulbactam_Sodium" @default.
- NCIT_C28823 NCIT_P399 "500377" @default.
- NCIT_C28823 normalizedInformationContent "100" @default.
- NCIT_C28823 referenceCount "1" @default.
- NCIT_C28823 hasExactSynonym "SULTAMICILLIN" @default.
- NCIT_C28823 hasExactSynonym "Sultamicillin" @default.
- NCIT_C28823 hasExactSynonym "Unasyn" @default.
- NCIT_C28823 inSubset NCIT_C176424 @default.
- NCIT_C28823 inSubset NCIT_C63923 @default.
- NCIT_C28823 type Class @default.
- NCIT_C28823 isDefinedBy ncit.owl @default.
- NCIT_C28823 label "Sultamicillin" @default.
- NCIT_C28823 subClassOf NCIT_C1908 @default.
- NCIT_C28823 subClassOf NCIT_C1909 @default.
- NCIT_C28823 subClassOf NCIT_C2166 @default.
- NCIT_C28823 subClassOf NCIT_C254 @default.
- NCIT_C28823 subClassOf NCIT_C28823 @default.