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- NCIT_C28826 IAO_0000115 "The hydrochloride salt of a synthetic quinazoline derivative, Anagrelide Hydrochloride reduces platelet production through a decrease in megakaryocyte maturation. Anagrelide inhibits cyclic AMP phosphodiesterase, as well as ADP- and collagen-induced platelet aggregation. At therapeutic doses, it does not influence white cell counts or coagulation parameters. Anagrelide is used for treatment of essential thrombocythemia to reduce elevated platelet counts and the risk of thrombosis. (NCI04)" @default.
- NCIT_C28826 NCIT_A6 NCIT_C28825 @default.
- NCIT_C28826 NCIT_NHC0 "C28826" @default.
- NCIT_C28826 NCIT_P106 "Organic Chemical" @default.
- NCIT_C28826 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C28826 NCIT_P108 "Anagrelide Hydrochloride Anhydrous" @default.
- NCIT_C28826 NCIT_P175 "724577" @default.
- NCIT_C28826 NCIT_P208 "CL1793002" @default.
- NCIT_C28826 NCIT_P210 "58579-51-4" @default.
- NCIT_C28826 NCIT_P319 "VNS4435G39" @default.
- NCIT_C28826 NCIT_P322 "FDA" @default.
- NCIT_C28826 NCIT_P329 "759095" @default.
- NCIT_C28826 NCIT_P330 "759095" @default.
- NCIT_C28826 NCIT_P350 "C10H7Cl2N3O.ClH" @default.
- NCIT_C28826 NCIT_P366 "Anagrelide_Hydrochloride" @default.
- NCIT_C28826 NCIT_P368 "CHEBI:55345" @default.
- NCIT_C28826 NCIT_P399 "759095" @default.
- NCIT_C28826 normalizedInformationContent "100" @default.
- NCIT_C28826 referenceCount "1" @default.
- NCIT_C28826 hasExactSynonym "ANAGRELIDE HYDROCHLORIDE ANHYDROUS" @default.
- NCIT_C28826 hasExactSynonym "Anagrelide Hydrochloride Anhydrous" @default.
- NCIT_C28826 inSubset NCIT_C176424 @default.
- NCIT_C28826 inSubset NCIT_C63923 @default.
- NCIT_C28826 type Class @default.
- NCIT_C28826 isDefinedBy ncit.owl @default.
- NCIT_C28826 label "Anagrelide Hydrochloride Anhydrous" @default.
- NCIT_C28826 subClassOf NCIT_C1327 @default.
- NCIT_C28826 subClassOf NCIT_C1908 @default.
- NCIT_C28826 subClassOf NCIT_C1909 @default.
- NCIT_C28826 subClassOf NCIT_C28826 @default.
- NCIT_C28826 subClassOf NCIT_C78275 @default.